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High-throughput profiling of influenza A virus hemagglutinin gene at single-nucleotide resolution
Genetic research on influenza virus biology has been informed in large part by nucleotide variants present in seasonal or pandemic samples, or individual mutants generated in the laboratory, leavingExpand
High-Throughput Identification of Loss-of-Function Mutations for Anti-Interferon Activity in the Influenza A Virus NS Segment
ABSTRACT Viral proteins often display several functions which require multiple assays to dissect their genetic basis. Here, we describe a systematic approach to screen for loss-of-function mutationsExpand
The Next Library Leadership: Attributes of Academic and Public Library Directors
Preface A Shortage of Librarians Qualities Expected of Library Directors: A Review of the Literature Qualities for ARL Directors Qualities for ACRL Directors Qualities for Public Library DirectorsExpand
Systematic Identification of H274Y Compensatory Mutations in Influenza A Virus Neuraminidase by High-Throughput Screening
ABSTRACT Compensatory mutations contribute to the appearance of the oseltamivir resistance substitution H274Y in the neuraminidase (NA) gene of H1N1 influenza viruses. Here, we describe aExpand
Coupling high-throughput genetics with phylogenetic information reveals an epistatic interaction on the influenza A virus M segment
BackgroundEpistasis is one of the central themes in viral evolution due to its importance in drug resistance, immune escape, and interspecies transmission. However, there is a lack of experimentalExpand