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Letter: Studies on the mechanism of chemical radioprotection by dimethyl sulphoxide.
Radioprotection by DMSO of mammalian cells exposed to X-rays and to heavy charged-particle beams
SummaryPopulations of G1-phase Chinese hamster cells in stirred suspensions containing various concentrations of DMSO were irradiated with 250 kV X-rays or various heavy charged-particle beams.Expand
Chemical radioprotection and radiosensitization of mammalian cells growing in vitro.
The radiosensitizing and radioprotective effects of various compounds have been characterized in Chinese hamster fibroblasts growing in vitro and in a model chemical system utilizing DNA as target.Expand
The inactivation of Chinese hamster cells by x rays: synchronized and exponential cell populations.
Reproductive survival of irradiated Chinese hamster fibroblasts is adequately described at all cell ages by an equation of the form $S/S_{0}={\rm exp}(-\alpha D-\beta D^{2})$. The two terms may beExpand
Nitrofurans as radiosensitizers of hypoxic mammalian cells.
Summary Our studies showed that various nitrofuran derivatives have excellent radiosensitizing properties in hypoxic Chinese hamster cells at concentrations at which there is no effect on platingExpand
Effectiveness of nitrofuran derivatives in sensitizing hypoxic mammalian cells to x rays.
Abstract Various nitrofuran derivatives have been tested with Chinese hamster cells growing in vitro to determine their toxicity and radiosensitizing effectiveness. All nitrofurans tested displayed aExpand
Radiation-induced strand breakage in mammalian cell DNA. I. Enhancement of single-strand breaks by chemical radiosensitizers.
SummaryChinese hamster cells irradiated with x-rays in complete medium while attached to glass surfaces and equilibrated with either air or nitrogen have been subsequently assayed for bothExpand
Competitive radioprotection and radiosensitization in chemical systems.
threshold for sensitization occurs at a sensitizer redox potential of approximately -0.3 V vs SCE required to oxidise the DNA radicals. The nitrofurans add to and oxidize DNA target radicals,Expand
Potential Use of Nitrofurans in Radiotherapy
IT has been suggested that the hypoxic centres within a tumour mass are likely to be relatively resistant to sterilization by ionizing radiation1. Compounds which could be introduced into suchExpand