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THE FORMATION OF 6-MERCAPTOPURINE RIBOSIDE PHOSPHATE IN ASCITES TUMOR CELLS
- A. P. Paterson
- Biology, Chemistry
- 1 August 1959
A nucleotide metabolite of 6-mercaptopurine has been isolated from Erhlich ascites carcinoma cells exposed to this compound under in vivo and in vitro conditions. By chemical and enzymatic methods,… Expand
Purine synthesis in suspensions of mucosa from the small intestine of the rat.
Suspensions of the epithelial lining of the small intestine of the rat have been shown to be suitable for in vitro studies of the de novo pathway of purine biosynthesis. The mucosal suspensions… Expand
Cytotoxicity of 2‐chlorodeoxyadenosine and arabinosylcytosine in leukaemic lymphoblasts from paediatric patients: significance of cellular nucleoside transporter content
- Adrienne M. P. Wright, A. P. Paterson, B. Sowa, J. Akabutu, P. Grundy, W. P. Gati
- British journal of haematology
- 1 March 2002
Summary. 2‐chlorodeoxyadenosine (2‐CdA) and arabinosylcytosine (araC) are nucleoside drugs that are used to treat various leukaemias, although 2‐CdA has not been tested extensively in children with… Expand
THE DE NOVO PATHWAY OF PYRIMIDINE NUCLEOTIDE BIOSYNTHESIS
This chapter discusses the de novo pathway of pyrimidine nucleotide biosynthesis. Animals do not have a dietary requirement for pyrimidines, and many microorganisms do not require exogenous… Expand
The metabolism of 2-C14-adenine in the rat.
The metabolism of 2-C14-adenine has been studied in the rat. Following intraperitoneal injection of the labelled material, isotope was found in the adenine and guanine of the visceral nucleic acids.… Expand