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The cuticle.
The nematode cuticle is an extremely flexible and resilient exoskeleton that permits locomotion via attachment to muscle, confers environmental protection and allows growth by molting. It isExpand
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Caenorhabditis elegans exoskeleton collagen COL‐19: An adult‐specific marker for collagen modification and assembly, and the analysis of organismal morphology
The integral role that collagens play in the morphogenesis of the nematode exoskeleton or cuticle makes them a useful marker in the examination of the collagen synthesizing machinery. In this study,Expand
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Biochemical and Structural Characterization of a Divergent Loop Cyclophilin from Caenorhabditis elegans *
Cyclophilin 3 (CYP-3) is one of the most abundantly expressed cyclophilin isoforms in the free living nematodeCaenorhabditis elegans. The detailed post-embryonic expression pattern of the cyp-3Expand
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Prolyl 4-Hydroxylase Is an Essential Procollagen-Modifying Enzyme Required for Exoskeleton Formation and the Maintenance of Body Shape in the Nematode Caenorhabditis elegans
ABSTRACT The multienzyme complex prolyl 4-hydroxylase catalyzes the hydroxylation of proline residues and acts as a chaperone during collagen synthesis in multicellular organisms. The β subunit ofExpand
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Combined Extracellular Matrix Cross-linking Activity of the Peroxidase MLT-7 and the Dual Oxidase BLI-3 Is Critical for Post-embryonic Viability in Caenorhabditis elegans*
The nematode cuticle is a protective collagenous extracellular matrix that is modified, cross-linked, and processed by a number of key enzymes. This Ecdysozoan-specific structure is synthesizedExpand
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A conserved metalloprotease mediates ecdysis in Caenorhabditis elegans
Molting is required for progression between larval stages in the life cycle of nematodes. We have identified four mutant alleles of a Caenorhabditis elegans metalloprotease gene, nas-37, that causeExpand
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Enzymes involved in the biogenesis of the nematode cuticle.
Nematodes include species that are significant parasites of man, his domestic animals and crops, and cause chronic debilitating diseases in the developing world; such as lymphatic filariasis andExpand
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Enzymology of the nematode cuticle: A potential drug target?
Graphical abstract
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Baculovirus expression of two protein disulphide isomerase isoforms from Caenorhabditis elegans and characterization of prolyl 4-hydroxylases containing one of these polypeptides as their beta
Protein disulphide isomerase (PDI; EC 5.3.4.1) is a multifunctional polypeptide that is identical to the beta subunit of prolyl 4-hydroxylases. We report here on the cloning and expression of theExpand
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The Exoskeleton Collagens in Caenorhabditis elegans Are Modified by Prolyl 4-Hydroxylases with Unique Combinations of Subunits*
The collagen prolyl 4-hydroxylases (P4Hs, EC1.14.11.2) play a critical role in the synthesis of the extracellular matrix. The enzymes characterized from vertebrates andDrosophila are α2β2 tetramers,Expand
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