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Lead exposure during synaptogenesis alters vesicular proteins and impairs vesicular release: potential role of NMDA receptor-dependent BDNF signaling.
Lead (Pb(2+)) exposure is known to affect presynaptic neurotransmitter release in both in vivo and cell culture models. However, the precise mechanism by which Pb(2+) impairs neurotransmitter releaseExpand
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Lead exposure during synaptogenesis alters NMDA receptor targeting via NMDA receptor inhibition.
N-methyl-D-aspartate receptor (NMDAR) ontogeny and subunit expression are altered during developmental lead (Pb²+) exposure. However, it is unknown whether these changes occur at the synaptic orExpand
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Molecular Neurobiology of Lead (Pb2+): Effects on Synaptic Function
Lead (Pb2+) is a ubiquitous environmental neurotoxicant that continues to threaten public health on a global scale. Epidemiological studies have demonstrated detrimental effects of Pb2+ on childhoodExpand
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Pyrethroids and Their Effects on Ion Channels
Ion channels are integral membrane proteins that are critical for neuronal function. They form pores in the plasma membrane that allow certain ions to travel with their concentration gradient acrossExpand
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Mechanisms of lead and manganese neurotoxicity.
Human exposure to neurotoxic metals is a global public health problem. Metals which cause neurological toxicity, such as lead (Pb) and manganese (Mn), are of particular concern due to theExpand
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Allethrin differentially modulates voltage-gated calcium channel subtypes in rat PC12 cells.
Pyrethroid insecticides are one of the most widely used classes of insecticides. Previous studies revealed that pyrethroids potently affect the insect voltage-gated sodium (Na(+)) channel (VGSC),Expand
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Enhanced nitric oxide production during lead (Pb2+) exposure recovers protein expression but not presynaptic localization of synaptic proteins in developing hippocampal neurons
We have previously reported that lead (Pb(2+)) exposure results in both presynaptic and postsynaptic changes in developing neurons as a result of inhibition of the N-methyl-d-aspartate receptorExpand
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Mechanisms of Heavy Metal Neurotoxicity: Lead and Manganese
Human exposure to heavy metals is a global public health problem. Heavy metals which cause neurological toxicity, such as lead (Pb2+) and manganese (Mn), are of particular concern due to theExpand
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CaMKK–CaMKI Signaling Pathways Differentially Control Axon and Dendrite Elongation in Cortical Neurons
Axonal and dendritic outgrowth is an integral component of both initial neural development and neuronal regeneration. Both axon and dendrite outgrowth are activity dependent, and recent evidence hasExpand
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Channelopathies: summary of the hot topic keynotes session.
The "Hot Topic Keynotes: Channelopathies" session of the 26th International Neurotoxicology Conference brought together toxicologists studying interactions of environmental toxicants with ionExpand
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