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Structural stability of adenovirus type 5.
Thermally induced structural changes in adenovirus type 5 (Ad) in the presence of either 2 or 10% sucrose were investigated using a variety of biophysical techniques. In solutions containing 2%Expand
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Chiral Amine Synthesis Using ω-Transaminases: An Amine Donor that Displaces Equilibria and Enables High-Throughput Screening**
The widespread application of ω-transaminases as biocatalysts for chiral amine synthesis has been hampered by fundamental challenges, including unfavorable equilibrium positions and productExpand
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Role of laccase as an enzymatic pretreatment method to improve lignocellulosic saccharification
The recalcitrant nature of lignocellulose, in particular due to the presence of lignin, is found to decrease the efficiency of cellulases during the saccharification of biomass. The efficient andExpand
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Engineering an enantioselective amine oxidase for the synthesis of pharmaceutical building blocks and alkaloid natural products.
The development of cost-effective and sustainable catalytic methods for the production of enantiomerically pure chiral amines is a key challenge facing the pharmaceutical and fine chemicalExpand
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Discrimination of epimeric glycans and glycopeptides using IM-MS and its potential for carbohydrate sequencing
Mass spectrometry is the primary analytical technique used to characterize the complex oligosaccharides that decorate cell surfaces. Monosaccharide building blocks are often simple epimers, whichExpand
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Bottom-Up Elucidation of Glycosidic Bond Stereochemistry.
The lack of robust, high-throughput, and sensitive analytical strategies that can conclusively map the structure of glycans has significantly hampered progress in fundamental and applied aspects ofExpand
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Chemoenzymatic synthesis of O-mannosylpeptides in solution and on solid phase.
O-mannosyl glycans are known to play an important role in regulating the function of α-dystroglycan (α-DG), as defective glycosylation is associated with various phenotypes of congenital muscularExpand
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Enzymes with noncanonical amino acids.
Enzyme design and engineering strategies rely almost exclusively on nature's alphabet of twenty canonical amino acids. Recent years have seen the emergence of powerful genetic code expansion methodsExpand
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The effect of stress and indomethacin, carbenoxolone, salbutamol, metiamide, zolimidine and CF19415 on rat gastric mucus
A method for measuring mucus adherent to the gastric mucosa using the dye alcian blue has been evaluated. Mucus was reduced by cold‐restraint stress, reserpine and pyloric ligation, but not by 18 hExpand
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A Noncanonical Proximal Heme Ligand Affords an Efficient Peroxidase in a Globin Fold.
Expanding the range of genetically encoded metal coordination environments accessible within tunable protein scaffolds presents excellent opportunities for the creation of metalloenzymes withExpand
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