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Syncytin: the major regulator of trophoblast fusion? Recent developments and hypotheses on its action.
- A. Pötgens, S. Drewlo, M. Kokozidou, P. Kaufmann
- Medicine, Biology
- Human reproduction update
- 1 November 2004
Syncytin is a membrane protein derived from the envelope gene of an endogenous retrovirus of the HERV-W family. The gene appears to be almost exclusively expressed in placenta; the protein was found… Expand
A two-colour fluorescence assay for the measurement of syncytial fusion between trophoblast-derived cell lines.
Syncytial fusion is a key event in implantation and placentation. Its regulation is only poorly understood. We present a cell-cell fusion assay based on staining of cells in two portions with a green… Expand
Characterization of trophoblast cell isolations by a modified flow cytometry assay.
The purity of isolated trophoblast cells is an important checkpoint in in vitro studies on the human placenta. Maintaining viability of primary cells for a prolonged period, or achieving cell… Expand
The Molecular Role of Connexin 43 in Human Trophoblast Cell Fusion1
ABSTRACT Connexin expression and gap junctional intercellular communication (GJIC) mediated by connexin 43 (Cx43)/gap junction A1 (GJA1) are required for cytotrophoblast fusion into the syncytium,… Expand
Mechanisms of syncytial fusion: a review.
- A. Pötgens, U. Schmitz, P. Bose, A. Versmold, P. Kaufmann, H. Frank
- Biology, Medicine
- 1 April 2002
Syncytial fusion of trophoblast is a key process in placental morphogenesis and physiology. Disturbed syncytial fusion may lead to a number of pregnancy-associated pathologies. The mechanisms… Expand
A positive immunoselection method to isolate villous cytotrophoblast cells from first trimester and term placenta to high purity.
We developed a method for isolating highly pure villous cytotrophoblast cells from first trimester and term placenta that excludes extravillous trophoblast and syncytiotrophoblast fragments. The… Expand
Cell culture models of human trophoblast: primary culture of trophoblast--a workshop report.
Erythropoietin mimetic compound AGEM400(HES) binds to the same receptor as erythropoietin but displays a different spectrum of activities.
EPO mimetic peptides (EMPs) have a completely different structure than erythropoietin (EPO) or new generation recombinant erythropoiesis stimulating agents (ESAs) like Darbepoietin alfa (Aranesp) and… Expand
C-Terminal truncations of syncytin-1 (ERVWE1 envelope) that increase its fusogenicity
- S. Drewlo, S. Leyting, M. Kokozidou, F. Mallet, A. Pötgens
- Biology, Medicine
- Biological chemistry
- 1 August 2006
Abstract Syncytin-1, the envelope protein of ERVWE1, an endogenous retrovirus of the HERV-W family, plays an important role in regulating fusion of the placental trophoblast. At least one of its… Expand
Y chromosomal fertility genes of Drosophila: a new type of eukaryotic genes.
The Y chromosomal fertility genes of Drosophila are required for sperm differentiation. They are active only in primary spermatocytes where they form giant lampbrush loops. The molecular structure of… Expand