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Mammalian defensins in the antimicrobial immune response
Defensins are peptidic components of the innate immune system of plants and animals. In mammals, defensins have evolved to have a central function in the host defense properties of granulocyticExpand
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Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense.
Precursors of alpha-defensin peptides require activation for bactericidal activity. In mouse small intestine, matrilysin colocalized with alpha-defensins (cryptdins) in Paneth cell granules, and inExpand
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A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins.
Analysis of rhesus macaque leukocytes disclosed the presence of an 18-residue macrocyclic, tridisulfide antibiotic peptide in granules of neutrophils and monocytes. The peptide, termed rhesus thetaExpand
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Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria.
Paneth cells in mouse small intestinal crypts secrete granules rich in microbicidal peptides when exposed to bacteria or bacterial antigens. The dose-dependent secretion occurs within minutes andExpand
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Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2-/- mice.
Anterior Gradient 2 (AGR2) is a protein disulfide isomerase that plays important roles in diverse processes in multiple cell lineages as a developmental regulator, survival factor and susceptibilityExpand
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Secretion of microbicidal α-defensins by intestinal Paneth cells in response to bacteria
Paneth cells in mouse small intestinal crypts secrete granules rich in microbicidal peptides when exposed to bacteria or bacterial antigens. The dose-dependent secretion occurs within minutes andExpand
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Enteric defensins: antibiotic peptide components of intestinal host defense
Five intestinal defensins, termed cryptdins 1-5, have been purified from mouse small bowel, sequenced, and localized to the epithelium by immunohistochemistry. Although identified as members of theExpand
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Mouse Paneth cell defensins: primary structures and antibacterial activities of numerous cryptdin isoforms.
Cryptdins are antimicrobial peptides of the defensin family that are produced by intestinal Paneth cells. mRNAs encoding 17 cryptdin isoforms have been characterized from a cDNA library generatedExpand
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Criterion for amino acid composition of defensins and antimicrobial peptides based on geometry of membrane destabilization.
Defensins comprise a potent class of membrane disruptive antimicrobial peptides (AMPs) with well-characterized broad spectrum and selective microbicidal effects. By using high-resolution synchrotronExpand
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Paneth cells and innate mucosal immunity
  • A. Ouellette
  • Biology, Medicine
  • Current opinion in gastroenterology
  • 1 November 2010
Purpose of review Recent evidence shows that disruption of Paneth cell homeostasis by induction of endoplasmic reticulum stress or autophagy, with consequent apoptosis, contributes to inflammationExpand
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