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Francisella tularensis LPS induces the production of cytokines in human monocytes and signals via Toll-like receptor 4 with much lower potency than E. coli LPS.
Francisella tularensis is a virulent Gram-negative intracellular pathogen. To address the signaling routes involved in the response of host cells to LPS from F. tularensis live vaccine strain (LVS),Expand
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Evaluation of an Immunocapture-Agglutination Test (Brucellacapt) for Serodiagnosis of Human Brucellosis
ABSTRACT We evaluated the validity and the usefulness of a new test for the diagnosis of human brucellosis based on an immunocapture-agglutination technique. A total of 315 sera from 82 patients withExpand
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Interaction of endotoxins with Toll-like receptor 4 correlates with their endotoxic potential and may explain the proinflammatory effect of Brucella spp. LPS.
Endotoxins displaying differences in the chemical structure of their lipid A were used to induce the expression of chemokines in the human monocytic THP-1 cell line. LPS from two enterobacterialExpand
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Lipopolysaccharides of Brucella abortusand Brucella melitensis Induce Nitric Oxide Synthesis in Rat Peritoneal Macrophages
ABSTRACT Smooth lipopolysaccharide (S-LPS) and lipid A of Brucella abortus and Brucella melitensis induced the production of nitric oxide (NO) by rat adherent peritoneal cells, but they induced lowerExpand
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Fas-Activated Serine/Threonine Phosphoprotein Promotes Immune-Mediated Pulmonary Inflammation
We generated Fas-activated serine threonine phosphoprotein (FAST)-deficient mice (FAST−/−) to study the in vivo role of FAST in immune system function. In a model of house dust mite-induced allergicExpand
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A new approach to determine the susceptibility of bacteria to antibiotics directly from positive blood culture bottles in two hours.
The rapid identification and antibiotic susceptibility test of bacteria causing bloodstream infections are given a very high priority by clinical laboratories. In an effort to reduce the timeExpand
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Serologic evidence of human infection by Francisella tularensis in the population of Castilla y León (Spain) prior to 1997.
Prior to an outbreak in Castilla y León in December 1997, tularaemia was practically non-existent in Spain. In this paper we studied the prevalence of antibodies against Francisella tularensis in aExpand
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Molecular Investigation of Tularemia Outbreaks, Spain, 1997–2008
This disease has reemerged because of persistence of local reservoirs of infection.
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Intraocular inflammation as the main manifestation of Rickettsia conorii infection
Objective To report the clinical features and management of seven cases of intraocular inflammation caused by Rickettsia infection and review published literature. Methods Rickettsia conorii orExpand
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Selective attenuation of Toll-like receptor 2 signalling may explain the atheroprotective effect of sphingosine 1-phosphate.
AIMS Vascular inflammation is a major atherogenic factor and Toll-like receptor (TLR) 2 ligands, including bacterial and serum lipoproteins, seem to be involved in atherogenesis. On this basis, weExpand
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