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Effects of dalcetrapib in patients with a recent acute coronary syndrome.
- G. Schwartz, A. Olsson, +14 authors R. S. Wright
- The New England journal of medicine
- 28 November 2012
BACKGROUND In observational analyses, higher levels of high-density lipoprotein (HDL) cholesterol have been associated with a lower risk of coronary heart disease events. However, whether raising HDL… Expand
High-dose atorvastatin vs usual-dose simvastatin for secondary prevention after myocardial infarction: the IDEAL study: a randomized controlled trial.
CONTEXT Evidence suggests that more intensive lowering of low-density lipoprotein cholesterol (LDL-C) than is commonly applied clinically will provide further benefit in stable coronary artery… Expand
Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes: the MIRACL study: a randomized controlled trial.
CONTEXT Patients experience the highest rate of death and recurrent ischemic events during the early period after an acute coronary syndrome, but it is not known whether early initiation of treatment… Expand
Cholesterol Lowering With Simvastatin Improves Prognosis of Diabetic Patients With Coronary Heart Disease: A subgroup analysis of the Scandinavian Simvastatin Survival Study (4S)
- K. Pyörälä, T. Pedersen, J. Kjekshus, O. Faergeman, A. Olsson, G. Thorgeirsson
- Diabetes Care
- 1 April 1997
OBJECTIVE To assess in diabetic patients with coronary heart disease (CHD) the effect of cholesterol lowering with simvastatin on mortality and the risk of CHD and other atherosclerotic events.… Expand
Influence of Low High-Density Lipoprotein Cholesterol and Elevated Triglyceride on Coronary Heart Disease Events and Response to Simvastatin Therapy in 4S
- C. Ballantyne, A. Olsson, T. Cook, M. Mercuri, T. Pedersen, J. Kjekshus
- 18 December 2001
Background—Patients with low HDL cholesterol (HDL-C) and elevated triglyceride had an increased risk for coronary heart disease (CHD) events and received the greatest benefit with fibrate therapy in… Expand
The effects of simvastatin on the incidence of heart failure in patients with coronary heart disease.
- J. Kjekshus, T. Pedersen, A. Olsson, O. Faergeman, K. Pyörälä
- Journal of cardiac failure
- 1 December 1997
BACKGROUND Although treatment of myocardial overload effectively reduces death from progression of heart failure, it is not known whether the retardation of progressive coronary artery disease… Expand
High-density lipoprotein cholesterol, high-density lipoprotein particle size, and apolipoprotein A-I: significance for cardiovascular risk: the IDEAL and EPIC-Norfolk studies.
- W. A. van der Steeg, I. Holme, +10 authors J. Kastelein
- Journal of the American College of Cardiology
- 12 February 2008
OBJECTIVES This study was designed to assess the relationship of high-density-lipoprotein cholesterol (HDL-C), HDL particle size, and apolipoprotein A-I (apoA-I) with the occurrence of coronary… Expand
High-Dose Atorvastatin Enhances the Decline in Inflammatory Markers in Patients With Acute Coronary Syndromes in the MIRACL Study
Background—Inflammation promotes acute coronary syndromes and ensuing clinical complications. Although statins reduce inflammatory markers in asymptomatic adults or in patients with stable angina,… Expand
Lipids, Apolipoproteins, and Their Ratios in Relation to Cardiovascular Events With Statin Treatment
Background— Low-density lipoprotein (LDL) cholesterol is the principal target of lipid-lowering therapy, but recent evidence has suggested more appropriate targets. We compared the relationships of… Expand
Cost effectiveness of simvastatin treatment to lower cholesterol levels in patients with coronary heart disease. Scandinavian Simvastatin Survival Study Group.
- M. Johannesson, B. Joensson, J. Kjekshus, A. Olsson, T. Pedersen, H. Wedel
- The New England journal of medicine
- 30 January 1997
BACKGROUND The Scandinavian Simvastatin Survival Study (4S) showed that lowering cholesterol levels with simvastatin reduces mortality and morbidity in patients with angina pectoris or previous acute… Expand