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Myocyte enhancer factor 2 (MEF2)-binding site is required for GLUT4 gene expression in transgenic mice. Regulation of MEF2 DNA binding activity in insulin-deficient diabetes.
TLDR
DNA binding activity was substantially reduced in nuclear extracts isolated from both heart and skeletal muscle of diabetic mice, which correlated with decreased transcription rate of the GLUT4 gene. Expand
Structure, function, and regulation of the mammalian facilitative glucose transporter gene family.
TLDR
The facilitative transport of glucose across the plasma membranes of mammalian cells is catalyzed by a family of glucose transport proteins (GLUT) that have unique tissue distributions and biochemical properties under- lying specific physiologic functions. Expand
Regulation of muscle GLUT-4 transcription by AMP-activated protein kinase.
TLDR
AMP-activated protein kinase activation by AICAR increases GLut-4 transcription by a mechanism that requires response elements within 895 bp of human GLUT-4 proximal promoter and that may be cooperatively mediated by myocyte enhancer factor-2. Expand
Regulation of muscle GLUT4 enhancer factor and myocyte enhancer factor 2 by AMP-activated protein kinase.
TLDR
It is concluded that GEF and MEF2 mediate the AMPK-induced increase in transcription of skeletal muscle GLUT4 and increase in binding to theGLUT4 promoter within 2 h after AICAR treatment. Expand
Syntaxin 4, VAMP2, and/or VAMP3/cellubrevin are functional target membrane and vesicle SNAP receptors for insulin-stimulated GLUT4 translocation in adipocytes
TLDR
Together, these data demonstrate that syntaxin 4, VAMP2, and/or VAMP3/cellubrevin can function as target membrane and vesicle SNAP receptors, respectively, for insulin-responsive GLUT4 translocation to the plasma membrane. Expand
Regulation of the human GLUT4 gene promoter: Interaction between a transcriptional activator and myocyte enhancer factor 2A
TLDR
A restricted pattern of GEF expression in human tissues is shown, which overlaps with MEF2A only in tissues expressing high levels of GLUT4, suggesting the hypothesis that GEF and MEF1A function together to activate GLUT3 transcription, and data obtained from transiently transfected cells support this hypothesis. Expand
Osmotic Shock Stimulates GLUT4 Translocation in 3T3L1 Adipocytes by a Novel Tyrosine Kinase Pathway*
TLDR
It is demonstrated that the osmotic shock stimulation of GLUT4 translocation in adipocytes occurs through a novel tyrosine kinase pathway that is independent of both the phosphatidylinositol 3-kinase and the Akt kinase. Expand
In vivo association of Grb2 with pp116, a substrate of the T cell antigen receptor-activated protein tyrosine kinase.
TLDR
It is reported that a GST/Grb2 fusion protein associates with several tyrosine phosphoproteins from lysates of T cell antigen receptor-stimulated Jurkat T cells, and it is demonstrated that pp116 binds the amino-terminal src homology 3 domain of Grb2, the same domain ofgrb2 thought to be primarily responsible for its interaction with SOS. Expand
Carnitine status of lactoovovegetarians and strict vegetarian adults and children.
TLDR
Differences in plasma carnitine concentrations were greater in children than in adults, possibly reflecting the effects of growth and tissue deposition, and small differences between diet groups in adults do not suggest a nutritionally significant difference in carnitines status. Expand
Identification of a 30-Base Pair Regulatory Element and Novel DNA Binding Protein That Regulates the Human GLUT4 Promoter in Transgenic Mice*
TLDR
The antibody raised against the Domain I binding protein inhibited formation of a Domain I-protein complex in electrophoretic mobility shift assays, indicating that the protein binding to Domain I is a novel protein. Expand
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