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The postnatal development of neocortical neurons and glial cells in the Göttingen minipig and the domestic pig brain
TLDR
The domestic pig seems to be a more suitable model for evaluating the effects of developmental insults on human brain growth and neuronal development than the Göttingen minipig. Expand
Behavioral response to novelty correlates with dopamine receptor availability in striatum of Göttingen minipigs
TLDR
Results show that propensity to explore an unfamiliar object is relatively elevated in pigs with low basal occupancy of dopamine D2/3 receptors by endogenous dopamine, and with high amphetamine-induced occupancy of released dopamine in the male pigs. Expand
MDMA‐evoked changes in [11C]raclopride and [11C]NMSP binding in living pig brain
TLDR
Distinct properties of MDMA such as simultaneous release of dopamine and serotonin in brain may account for the present finding of progressive decline in the availability of [11C]NMSP binding sites in striatum. Expand
Synthesis, radiolabeling and in vivo evaluation of [11C]RAL-01, a potential phosphodiesterase 5 radioligand.
TLDR
A radiosynthesis for the phosphodiesterase (PDE) 5 inhibitor [(11)C]RAL-01 shows considerable promise for PET studies of biliary elimination and of PDE5 binding in the cardiovascular system, however, analogues of higher affinity may be required for investigations of central nervous system binding sites. Expand
Usefulness of human coagulation and fibrinolysis assays in domestic pigs.
TLDR
It is concluded that human functional assays are useful in porcine plasma, whereas only a few immunologic assays can be used. Expand
MDMA‐evoked changes in cerebral blood flow in living porcine brain: Correlation with hyperthermia
TLDR
Individual differences in the susceptibility to MDMA‐induced hyperthermia in this population correlated with the magnitude of focal increases in CBF within specific brain regions endowed with a dense serotonin innervation, including regions linked to thermoregulation. Expand
Mapping the amphetamine-evoked dopamine release in the brain of the Göttingen minipig
TLDR
The spatial pattern of reactivity of dopamine D(2/3) receptor availability to amphetamine challenge is not identical in male and female pigs, and the decline in pB evoked by amphetamine was greater in the ventral striatum than in the caudate nucleus, consistent with earlier reports in monkeys and humans. Expand
A PET study of effects of chronic 3,4‐methylenedioxymethamphetamine (MDMA, “ecstasy”) on serotonin markers in Göttingen minipig brain
TLDR
MDMA depletion of serotonin innervations was not associated with consistent alterations in the binding of [11C]WAY‐100635 to serotonin 5HT1A receptors and stereological cell counting of serotonin‐positive neurons, which numbered 95,000 in the dorsal raphé nucleus of normal animals, was unaffected in MDMA‐treated group. Expand
Interaction between LSD and dopamine D2/3 binding sites in pig brain
TLDR
Results are consistent with a direct interaction between LSD and a portion of dopamine D2/3 receptors in pig brain, possibly contributing to the psychopharmacology of LSD. Expand
The Göttingen minipig as a model for postprandial hyperlipidaemia in man: experimental observations
TLDR
It is concluded that postprandial hyperlipidaemia in minipigs can be induced by gavaging an emulgated lipid solution (1-4 g fat/kg, Intralipid®), while olive oil is not applicable. Expand
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