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Metabolic Cardioprotection by Pyruvate: Recent Progress
Pyruvate, a natural metabolic fuel and antioxidant in myocardium and other tissues, exerts a variety of cardioprotective actions when provided at supraphysiological concentrations. Pyruvate increasesExpand
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Differential baroreflex control of heart rate in sedentary and aerobically fit individuals.
PURPOSE We compared arterial, aortic, and carotid-cardiac baroreflex sensitivity in eight average fit (maximal oxygen uptake, VO2max = 42.2+/-1.9 mL x kg(-1) x min(-1)) and eight high fit (VO2max =Expand
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Carotid baroreflex regulation of sympathetic nerve activity during dynamic exercise in humans.
We sought to determine whether carotid baroreflex (CBR) control of muscle sympathetic nerve activity (MSNA) was altered during dynamic exercise. In five men and three women, 23.8 +/- 0.7 (SE) yr ofExpand
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Strategic leukocyte depletion reduces pulmonary microvascular pressure and improves pulmonary status post-cardiopulmonary bypass
Cardiopulmonary bypass (CPB) precipitates inflammation that causes marked pulmonary dysfunction. Leukocyte filtration has been proposed to reduce these deleterious effects. Other studies show anExpand
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Increases in intramuscular pressure raise arterial blood pressure during dynamic exercise.
This investigation was designed to determine the role of intramuscular pressure-sensitive mechanoreceptors and chemically sensitive metaboreceptors in affecting the blood pressure response to dynamicExpand
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Intraoperative treatment strategy to reduce the incidence of postcardiopulmonary bypass atrial fibrillation
Purpose: Postcardiopulmonary bypass atrial fibrillation remains a constant complication associated with coronary revascularization, the incidence of which occurs from 20% to 35%. Previous studiesExpand
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Leukocyte filtration and aprotinin: synergistic anti-inflammatory protection
Cardiopulmonary bypass activates an array of cellular and humoral inflammatory mechanisms that culminate in diverse or organ-specific injury. A manifestation of inflammatory injury to the heart,Expand
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Acute lower leg hot water immersion protects macrovascular dilator function following ischaemia–reperfusion injury in humans
• What is the central question of this study? What is the effect of lower leg hot water immersion on vascular ischaemia–reperfusion injury induced in the arm of young healthy humans? • What is theExpand
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Pyruvate-enhanced cardioprotection during surgery with cardiopulmonary bypass.
OBJECTIVES To determine whether pyruvate-fortified cardioplegia solution provides cardioprotection superior to lactate-based cardioplegia solutions in patients undergoing elective coronaryExpand
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Pyruvate-fortified fluid resuscitation improves hemodynamic stability while suppressing systemic inflammation and myocardial oxidative stress after hemorrhagic shock.
OBJECTIVES To determine whether controlled resuscitation with pyruvate-fortified Ringer's (PR) solution vs. conventional lactate Ringer's (LR) more effectively stabilizes mean arterial pressure (MAP)Expand
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