• Publications
  • Influence
Metabolic Cardioprotection by Pyruvate: Recent Progress
TLDR
Basic and clinically oriented research conducted over the last several years that has yielded fundamental information on pyruvate's inotropic and cardioprotective mechanisms are reviewed and discussed, establishing the essential foundation for clinical application of pyruVate therapy in numerous settings.
Carotid baroreflex regulation of sympathetic nerve activity during dynamic exercise in humans.
TLDR
CBR control of sympathetic nerve activity appears to be preserved during moderate-intensity dynamic exercise, despite the marked increases in MAP and MSNA during exercise.
Strategic leukocyte depletion reduces pulmonary microvascular pressure and improves pulmonary status post-cardiopulmonary bypass
TLDR
It is conceivable that a timely use of arterial line leukoreducing filters may improve, more substantially, pulmonary function postbypass.
Inhibition of KATP channel activity augments baroreflex‐mediated vasoconstriction in exercising human skeletal muscle
TLDR
It is indicated that KATP channel activity modulates sympathetic vasoconstriction in humans and may prove to be an important mechanism by which functional sympatholysis operates in humans during exercise.
Differential baroreflex control of heart rate in sedentary and aerobically fit individuals.
TLDR
These data confirm that reductions in arterial-cardiac reflex sensitivity are mediated by diminished ABR function and suggest that the integrative relationship between the ABR and CBR contributing to arterial baroreflex control of HR is inhibitory in nature and not altered by exercise training.
Carotid baroreflex control of leg vasculature in exercising and non‐exercising skeletal muscle in humans
TLDR
Data indicate that, despite a clear attenuation of the vascular response to MSNA in the exercising leg, CBR‐mediated changes in mean arterial pressure were no different between rest and exercise.
Increases in intramuscular pressure raise arterial blood pressure during dynamic exercise.
TLDR
It is suggested that under normal conditions the mechanoreflex is tonically active and is the primary mediator of exercise pressor reflex-induced alterations in arterial blood pressure during submaximal dynamic exercise in humans.
Intraoperative treatment strategy to reduce the incidence of postcardiopulmonary bypass atrial fibrillation
TLDR
This novel intraoperative treatment strategy of both mechanical (leukocyte filtration) and pharmacological (aprotinin) intervention appears to markedly reduce the incidence of postcardiopulmonary bypass atrial fibrillation.
Leukocyte filtration and aprotinin: synergistic anti-inflammatory protection
TLDR
It is suggested that combining mechanical and pharmacologic suppression of the systemic inflammatory response could mitigate its deleterious arrhythmic and pulmonary complications.
Pyruvate enhancement of cardiac performance: Cellular mechanisms and clinical application
TLDR
Pyruvate’s myriad benefits in preclinical models provide the mechanistic framework for its clinical application as metabolic support for myocardium at risk and its antioxidant actions restore β-adrenergic signaling and suppress inflammation.
...
...