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Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure
Acetaminophen (APAP) is a safe analgesic and antipyretic drug. However, APAP overdose leads to massive hepatocyte death. Cell death during APAP toxicity occurs by oncotic necrosis, in which theExpand
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Changes in testicular morphology and steroidogenesis in adult rats exposed to Atrazine.
Atrazine is an herbicide considered as a potent endocrine disruptor, causing adverse effects on both gender of mammalian and non-mammalian species. Despite the known adverse effects of Atrazine,Expand
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Altered responsiveness to extracellular ATP enhances acetaminophen hepatotoxicity
BackgroundAdenosine triphosphate (ATP) is secreted from hepatocytes under physiological conditions and plays an important role in liver biology through the activation of P2 receptors. Conversely,Expand
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Effects of the herbicide Roundup on the epididymal region of drakes Anas platyrhynchos.
Exposure to the Roundup has been shown to affect StAR protein and aromatase expression and activity, pointing out that this herbicide may cause adverse effects in animal reproduction by affectingExpand
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Nucleoplasmic calcium signaling and cell proliferation: calcium signaling in the nucleus
Calcium (Ca2+) is an essential signal transduction element involved in the regulation of several cellular activities and it is required at various key stages of the cell cycle. Intracellular Ca2+ isExpand
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5alpha-Androstane-3beta,17beta-diol (3beta-diol), an estrogenic metabolite of 5alpha-dihydrotestosterone, is a potent modulator of estrogen receptor ERbeta expression in the ventral prostrate of
Prostate is one of the major targets for dihydrotestosterone (DHT), however this gland is also recognized as a nonclassical target for estrogen as it expresses both types of estrogen receptors (ER),Expand
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5α-Androstane-3β,17β-diol (3β-diol), an estrogenic metabolite of 5α-dihydrotestosterone, is a potent modulator of estrogen receptor ERβ expression in the ventral prostrate of adult rats
Prostate is one of the major targets for dihydrotestosterone (DHT), however this gland is also recognized as a nonclassical target for estrogen as it expresses both types of estrogen receptors (ER),Expand
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The insulin receptor translocates to the nucleus to regulate cell proliferation in liver
Insulin's metabolic effects in the liver are widely appreciated, but insulin's ability to act as a hepatic mitogen is less well understood. Because the insulin receptor (IR) can traffic to theExpand
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Distribution of estrogen receptors (ERalpha and ERbeta) and androgen receptor in the testis of big fruit-eating bat Artibeus lituratus is cell- and stage-specific and increases during gonadal
The testis is a classical target for androgens, especially testosterone, acting via androgen receptor (AR). Alternatively, androgens can be aromatized to produce estrogens which act via specificExpand
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Expression of the type 3 InsP3 receptor is a final common event in the development of hepatocellular carcinoma
Background & objectives Hepatocellular carcinoma (HCC) is the second leading cause of cancer death worldwide. Several types of chronic liver disease predispose to HCC, and several differentExpand
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