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Trafficking and Postsecretory Events Responsible for the Formation of Secreted Human Salivary Peptides
To elucidate the localization of post-translational modifications of different classes of human salivary proteins and peptides (acidic and basic proline-rich proteins (PRPs), Histatins, Statherin,Expand
The Surprising Composition of the Salivary Proteome of Preterm Human Newborn
This study shows for the first time that analysis of these proteins in saliva of preterm newborns might represent a noninvasive way to obtain precious information of the molecular mechanisms of development of human fetal oral structures. Expand
Structure/function relationships in the hemoglobin components from moray (Muraena helena).
The complete sequence of the beta chains of the cathodal and of one of the anodal components have been determined and the possible molecular basis of these different functional characteristics are discussed in the light of the globin sequence and of those amino acid residues which are known to be responsible of hemoglobin functional behaviour. Expand
Structural-functional characterization of the cathodic haemoglobin of the conger eel Conger conger: molecular modelling study of an additional phosphate-binding site.
A computer modelling study has been performed on the basis of the amino acid sequence of the alpha- and beta-chains, which suggest that C. conger cathodic Hb may bind organic phosphates at two distinct binding sites located along the central cavity of the tetramer by hydrogen bonds and/or electrostatic interactions with amino acid residues of both chains, which have been identified. Expand
A new site-specific monoPEGylated filgrastim derivative prepared by enzymatic conjugation: Production and physicochemical characterization.
The new site specific monoPEGylated filgrastim is a promising candidate for preclinical and clinical studies aimed at developing a long-lasting treatment of neutropenia in oncological patients under chemotherapy treatments. Expand
Determination of the human salivary peptides histatins 1, 3, 5 and statherin by high-performance liquid chromatography and by diode-array detection.
The reversed-phase high-performance liquid chromatography method with diode-array detection for the quantification of several human salivary peptides can be useful in assessing the concentration of salivaries from normal subjects and from patients suffering oral and/or periodontal diseases. Expand
Induction, purification, and characterization of a laccase isozyme from Pleurotus sajor-caju and the potential in decolorization of textile dyes
Ferulic acid causes a strain of Pleurotus sajor-caju to excrete large amounts of one laccase isozyme, that was purified to homogeneity. Ferulic acid was the best inductor for laccase in this fungalExpand
Oxygen-binding modulation of hemocyanin from the slipper lobster Scyllarides latus.
The oxygen-binding properties of hexameric hemocyanin from Scyllarides latus were investigated with respect to pH, temperature, and modulating effect exerted by calcium, lactate, and urate; urate markedly increased Hc-oxygen affinity and its temperature sensitivity, acting as the physiological major positive effector. Expand
δ-Opioid Receptors Stimulate the Metabolic Sensor AMP-Activated Protein Kinase through Coincident Signaling with Gq/11-Coupled Receptors
The data indicate that in different cell systems, DOR activation up-regulates AMPK through a Gβγ-dependent synergistic interaction with Gq/11-coupled receptors, potentiating Ca2+ release and CaMKKβ-dependent AMPK phosphorylation, which is involved in DOR-induced glucose uptake. Expand
Structural and functional characterization of haemocyanin from the anemone hermit crab Dardanus calidus.
Functional analysis performed on purified native, hexameric and dodecameric Hc forms of the anemone hermit crab Dardanus calidus allowed to calculate the enthalphy of oxygenation values, suggesting a high Hc functional heterogeneity within Anomura. Expand