Formulation of an ophthalmic lipid emulsion containing an anti-inflammatory steroidal drug, difluprednate.
- Masazumi Yamaguchi, Shin-ichi Yasueda, A. Ohtori
- Chemistry, MedicineInternational journal of pharmaceutics
- 14 September 2005
Effect of dicyclomine on intestinal absorption, disposition and biliary excretion of dexamethasone.
The effect of dicyclomine, a cholinergic blocking agent, on the in situ intestinal absorption, plasma clearance, biliary excretion, and renal plasma flow in coadministration group was significantly enhanced compared with that of dexamethasone alone.
In vivo/in vitro correlation of intravitreal delivery of drugs with the help of computer simulation.
The in vivo data of elimination of DMSB following intravitreal injection agreed with the profiles calculated from the mathematical model, together with the model parameters determined from the in vitro experiments, indicating that the present in vivo/in vitro correlation can be used for optimizing the therapeutic systems of intravItreal drug delivery.
Encapsulation of dexamethasone in rabbit erythrocytes, the disposition in circulation and anti-inflammatory effect.
The results indicated that resealed erythrocytes act as a slow release system in vivo, and the encapsulated cells were protected from inflammation (the capillary permeability response) caused by histamine for approximately 2 to 5 d after administration.
Development of a miniaturised drug delivery system with wireless power transfer and communication
- Stewart Smith, T. Tang, A. Walton
- 10 September 2007
The development of an implantable system designed to deliver drug doses in a controlled manner over an extended time period and the system has been designed to facilitate wireless power transfer, which is very important for miniaturisation as it removes the need for a battery.
Mucoadhesive properties of chitosan-coated ophthalmic lipid emulsion containing indomethacin in tear fluid.
- Masazumi Yamaguchi, Kayoko Ueda, K. Tojo
- Medicine, ChemistryBiological and Pharmaceutical Bulletin
- 1 July 2009
The findings indicated that retention of the drug in tears was appreciably prolonged by chitosan-coated emulsion, and that CE had higher distribution on the ocular surface than NE, and the drug levels in cornea, conjunctiva, and aqueous humor at 1 h after instillation were clearly higher than those of NE.
Implementation of wireless power transfer and communications for an implantable ocular drug delivery system.
This wireless power transfer and communication system based on near-field inductive coupling could replace a chemical battery in an implantable system, eliminating the risks associated with battery failure and leakage and also allowing more compact designs for applications such as drug delivery.
Evaluation of ophthalmic suspensions using surface tension.
- Shin-ichi Yasueda, Katsuhiro Inada, K. Matsuhisa, H. Terayama, A. Ohtori
- Materials Science, MedicineEuropean journal of pharmaceutics and…
- 1 March 2004
Hydrogel Ring for Topical Drug Delivery to the Ocular Posterior Segment
- Yuko Shikamura, Y. Yamazaki, T. Matsunaga, Takao Sato, A. Ohtori, K. Tojo
- Medicine, BiologyCurrent Eye Research
- 1 May 2016
The results suggest that hydrogel rings are effective in delivering topical ophthalmic drugs to the posterior segment of the rabbit eye and are most likely delivered via the transconjunctival/scleral route by lateral diffusion across the bulbar conjunctiva and through the sclera.
A pharmacokinetic model of intravitreal delivery of ganciclovir.
- K. Tojo, K. Nakagawa, Y. Morita, A. Ohtori
- Biology, MedicineEuropean journal of pharmaceutics and…
- 1 March 1999