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Degradation of phosphonates by streptomycete isolates
Streptomycete StC had a surprising ability to degrade N-phosphonomethylglycine (glyphosate) in a phosphate-independent manner via C–P bond cleavage accompanied by sarcosine formation. Expand
Organophosphonate Utilization by the Thermophile Geobacillus caldoxylosilyticus T20
ABSTRACT A strain of Geobacillus caldoxylosilyticus from central heating system water could utilize a number of organophosphonates as the sole phosphorus source for growth at 60°C. During growth onExpand
Phosphinothricin analogues as inhibitors of plant glutamine synthetases.
Kinetic analysis confirmed the ability of the phosphinothricin analogues to inhibit both isoenzymes in the micromolar range, with a mechanism of a competitive type with respect to glutamate. Expand
Utilisation of structurally diverse organophosphonates by Streptomycetes
Streptomyces morookaensis DSM 40565 could degrade 2-amino-4-phosphonobutyrate as a sole nitrogen and phosphorus source in a stereoselective-like manner, suggesting the existence of a new metabolic pathway for C–P bond breakage. Expand
Design, synthesis, and activity of analogues of phosphinothricin as inhibitors of glutamine synthetase.
In vitro kinetic studies with Escherichia coli glutamine synthetase confirmed the biological activity of the designed inhibitors, which with K(i) values in the micromolar range appear to be slightly weaker inhibitors or equipotent to phosphinothricin. Expand
Herbicidal pyridyl derivatives of aminomethylene-bisphosphonic acid inhibit plant glutamine synthetase.
A preliminary analysis of structure-activity relationship allowed it to be hypothesized that steric rather than electronic factors are responsible for the inhibitory potential of these compounds. Expand
Isolation and Characterization of two New Microbial Strains Capable of Degradation of the Naturally Occurring Organophosphonate––Ciliatine
Enzymatic activity involved in ciliatine degradation studied in the fungal cell-free extract proved to be distinct from bacterial pathway described before. Expand