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Antimalarials. Synthesis and antimalarial activity of 1-(4-methoxycinnamoyl)-4-(5-phenyl-4-oxo-2-oxazolin-2-yl)piperazine and derivatives.
Five compounds (three of them substituted in the para position of the 5-phenyl group and two N-arylpiperazine pemoline derivatives) were found to be active against Plasmodium berghei.
Local anesthetic activity and acute toxicity of N-substituted 1,2,3,4-tetrahydro-1- and 2-naphthylamines.
N-Heptyl-1,2,3,4-tetrahydro-6-methoxy-1-naphthylamine methanesulfonate was the most promising local anesthetic in these series and showed toxicity equal to or greater than tetracaine by the intraperitoneal route in mice.
Local anesthetic activity and acute toxicity of N-heptyl-1,2,3,4-tetrahydro-6-methoxy-1-naphthylamine methanesulfonate.
Comparison of the LD50 and TAC values in the mouse sciatic nerve block test indicated that I had a greater therapeutic index than either reference standard, and by either route, I was less toxic than tetracaine and more toxic than lidocaine.
Anticonvulsant drugs; some acylureas.