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SOX1 antibodies are markers of paraneoplastic Lambert–Eaton myasthenic syndrome
TLDR
The detection of SOX1 antibodies in patients with Lambert–Eaton myasthenic syndrome (LEMS) predicts the presence of small cell lung cancer and may be used to follow more closely those LEMS patients with no evidence of cancer at the initial workup.
Identification of multiple cancer/testis antigens by allogeneic antibody screening of a melanoma cell line library.
TLDR
The findings document the immunogenicity of LAGE-1 and CT7 and emphasize the power of serological analysis of cDNA expression libraries in identifying new human tumor antigens.
NY-ESO-1: review of an immunogenic tumor antigen.
Serological identification of embryonic neural proteins as highly immunogenic tumor antigens in small cell lung cancer.
TLDR
Serological analysis of expression cDNA libraries derived from two small cell lung cancer (SCLC) cell lines using pooled sera of SCLC patients led to the isolation of 14 genes, including 4 SOX group B genes and ZIC2, suggesting SOX1 and/or SOX2 as the main antigens eliciting anti-SOX responses.
Expression of SSX genes in human tumors
The HOM‐MEL‐40 antigen which is encoded by the SSX‐2 gene was originally detected as a tumor antigen recognized by autologous IgG antibodies in a melanoma patient. Expression analysis demonstrated
Human lung cancer antigens recognized by autologous antibodies: definition of a novel cDNA derived from the tumor suppressor gene locus on chromosome 3p21.3.
TLDR
Serological analysis of a recombinant lung cancer cDNA expression library with the autologous patient serum led to the isolation of 20 clones representing 12 different genes, of most interest was NY-LU-12, which was found to be derived from the same gene as g16, a partially sequenced gene that mapped to the lung cancer tumor suppressor gene locus on chromosome 3p21.
The SSX gene family: Characterization of 9 complete genes
TLDR
Three additional SSX genes are identified, SSX7, 8, 9, and the sequence of the formerly partially defined SSX6 gene is completed, indicating that mechanisms other than methylation or histone acetylation may be responsible for the repressed state of someSSX genes.
Identification of a tissue-specific putative transcription factor in breast tissue by serological screening of a breast cancer library.
TLDR
USGS analysis of a breast cancer library with autologous patient serum led to the isolation of seven genes, designated NY-BR-1 through NY- BR-7, which represents a breast tissue-specific putative transcription factor with autoimmunogenicity in breast cancer patients.
CT10: A new cancer‐testis (CT) antigen homologous to CT7 and the MAGE family, identified by representational‐difference analysis
TLDR
A serological survey identified 2 melanoma patients with anti‐CT10 antibody, demonstrating the immunogenicity of CT10 in humans, as well as a novel gene designated CT10, which shows strong homology to CT7/MAGE‐C1 both at cDNA and at genomic levels.
Cancer-testis antigens and ING1 tumor suppressor gene product are breast cancer antigens: characterization of tissue-specific ING1 transcripts and a homologue gene.
TLDR
Comparison of ING1 cDNA from normal and tumor tissues showed no mutation in the index breast cancer case and revealed the presence of at least three different mRNA transcripts with variable transcription initiation sites and exon usage, which need further exploration.
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