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Skip segment Hirschsprung’s disease: a systematic review
PurposeHirschsprung’s disease is characterised by the congenital absence of ganglion cells beginning in the distal rectum and extending proximally for varying distances. ‘Zonal aganglionosis’ is a… Expand
New Insights into the Neuromuscular Anatomy of the Ileocecal Valve
The neuroanatomy of the ileocecal valve (ICV) is poorly understood. A better understanding of this important functional component of the gastrointestinal tract would enable surgeons to reconstruct an… Expand
Adriamycin induces notochord hypertrophy with conservation of sonic hedgehog expression in abnormal ectopic notochord in the adriamycin rat model.
- A. Mortell, A. O'donnell, S. Giles, J. Bannigan, P. Puri
- Biology, Medicine
- Journal of pediatric surgery
- 1 June 2004
BACKGROUND/PURPOSE The Adriamycin rat model (ARM) is a well-established model of the Vertebral, Anorectal, Cardiac, Tracheoesophageal, Renal, Limb (VACTERL) association. The notochord, which… Expand
Altered distribution of small-conductance calcium-activated potassium channel SK3 in Hirschsprung's disease.
PURPOSE SK3 channels are voltage-independent Ca(2+)-dependent K(+) channels that play a key role in regulating smooth muscle membrane potential during purinergic inhibitory neurotransmission in the… Expand
"Tuft Cells": A New Player in Hirschsprung's Disease.
- A. O'donnell, Hiroki Nakamura, P. Puri
- European journal of pediatric surgery : official…
- 10 November 2019
INTRODUCTION "Tuft" cells, also known as brush or caveolated cells, are characteristically fusiform shaped, with a distinct apical "tuft" of microvilli extending into the lumen. Double cortin-like… Expand
Platelet-derived growth factor receptor alpha-positive cells: a new cell type in the human ureteropelvic junction
Background:Ureteropelvic junction (UPJ) obstruction is the most common cause of congenital hydronephrosis. Normal ureteral motility requires coordinated interaction between neurons, smooth muscle… Expand
Use of anoctamin 1 (ANO1) to evaluate interstitial cells of Cajal in Hirschsprung’s disease
- D. Coyle, Danielle Kelly, A. O'donnell, J. Gillick, P. Puri
- Pediatric Surgery International
- 1 February 2016
PurposeInterstitial cells of Cajal (ICCs) are pacemaker cells involved in facilitating neurotransmission and the generation of slow electrical waves necessary for colonic peristalsis. Their… Expand
Distribution and chemical coding of orphanin FQ/nociceptin‐immunoreactive neurons in the myenteric plexus of guinea pig intestines and sphincter of Oddi
- A. O'donnell, L. M. Ellis, M. Riedl, R. Elde, G. Mawe
- Biology, Medicine
- The Journal of comparative neurology
- 29 January 2001
Longitudinal muscle‐myenteric plexus preparations of guinea pig intestines and sphincter of Oddi (SO) were immunostained for orphanin FQ/nociceptin. Orphanin FQ‐immunoreactive (OFQ‐IR) neurons and… Expand
Deficiency of platelet-derived growth factor receptor-α-positive cells in Hirschsprung's disease colon.
AIM To investigate whether the expression of platelet-derived growth factor receptor-α-positive (PDGFRα(+))-cells is altered in Hirschsprung's disease (HD). METHODS HD tissue specimens (n = 10)… Expand
Altered neurotransmitter expression profile in the ganglionic bowel in Hirschsprung's disease.
PURPOSE Despite having optimal pull-through (PT) surgery for Hirschsprung's disease (HSCR), many patients experience persistent bowel symptoms with no mechanical/histopathological cause. Murine… Expand