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Skip segment Hirschsprung’s disease: a systematic review
PurposeHirschsprung’s disease is characterised by the congenital absence of ganglion cells beginning in the distal rectum and extending proximally for varying distances. ‘Zonal aganglionosis’ is aExpand
New Insights into the Neuromuscular Anatomy of the Ileocecal Valve
The neuroanatomy of the ileocecal valve (ICV) is poorly understood. A better understanding of this important functional component of the gastrointestinal tract would enable surgeons to reconstruct anExpand
Adriamycin induces notochord hypertrophy with conservation of sonic hedgehog expression in abnormal ectopic notochord in the adriamycin rat model.
BACKGROUND/PURPOSE The Adriamycin rat model (ARM) is a well-established model of the Vertebral, Anorectal, Cardiac, Tracheoesophageal, Renal, Limb (VACTERL) association. The notochord, whichExpand
Altered distribution of small-conductance calcium-activated potassium channel SK3 in Hirschsprung's disease.
PURPOSE SK3 channels are voltage-independent Ca(2+)-dependent K(+) channels that play a key role in regulating smooth muscle membrane potential during purinergic inhibitory neurotransmission in theExpand
"Tuft Cells": A New Player in Hirschsprung's Disease.
INTRODUCTION  "Tuft" cells, also known as brush or caveolated cells, are characteristically fusiform shaped, with a distinct apical "tuft" of microvilli extending into the lumen. Double cortin-likeExpand
Platelet-derived growth factor receptor alpha-positive cells: a new cell type in the human ureteropelvic junction
Background:Ureteropelvic junction (UPJ) obstruction is the most common cause of congenital hydronephrosis. Normal ureteral motility requires coordinated interaction between neurons, smooth muscleExpand
Use of anoctamin 1 (ANO1) to evaluate interstitial cells of Cajal in Hirschsprung’s disease
PurposeInterstitial cells of Cajal (ICCs) are pacemaker cells involved in facilitating neurotransmission and the generation of slow electrical waves necessary for colonic peristalsis. TheirExpand
Distribution and chemical coding of orphanin FQ/nociceptin‐immunoreactive neurons in the myenteric plexus of guinea pig intestines and sphincter of Oddi
Longitudinal muscle‐myenteric plexus preparations of guinea pig intestines and sphincter of Oddi (SO) were immunostained for orphanin FQ/nociceptin. Orphanin FQ‐immunoreactive (OFQ‐IR) neurons andExpand
Deficiency of platelet-derived growth factor receptor-α-positive cells in Hirschsprung's disease colon.
AIM To investigate whether the expression of platelet-derived growth factor receptor-α-positive (PDGFRα(+))-cells is altered in Hirschsprung's disease (HD). METHODS HD tissue specimens (n = 10)Expand
Altered neurotransmitter expression profile in the ganglionic bowel in Hirschsprung's disease.
PURPOSE Despite having optimal pull-through (PT) surgery for Hirschsprung's disease (HSCR), many patients experience persistent bowel symptoms with no mechanical/histopathological cause. MurineExpand
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