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Arginase-producing myeloid suppressor cells in renal cell carcinoma patients: a mechanism of tumor evasion.
Myeloid suppressor cells with high arginase activity are found in tumors and spleen of mice with colon and lung cancer. These cells, described as macrophages or immature dendritic cells, depleteExpand
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Cox-2 inhibition enhances the activity of sunitinib in human renal cell carcinoma xenografts
Background:Sunitinib (Su), a tyrosine kinase inhibitor of VEGFR, is effective at producing tumour response in clear cell renal cell carcinoma (cRCC), but resistance to therapy is inevitable. As COX-2Expand
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Apoptosis occurs independently of bcl‐2 and p53 over‐expression in non‐small cell lung carcinoma
Certain oncogenes and tumour suppressor genes are known to modulate apoptosis. To investigate whether over‐expressed bcl‐2 and abnormally stabilized p53 are associated with reduced apoptosis inExpand
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Extent of apoptosis in ovarian serous carcinoma: relation to mitotic and proliferative indices, p53 expression, and survival.
AIMS: To assess the extent of apoptosis in ovarian serous carcinoma and to examine possible relations between apoptosis, cell proliferation, p53 overexpression, and patient survival. METHODS:Expand
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Apoptotic and mitotic indices in malignant melanoma and basal cell carcinoma.
AIMS--To assess the relative frequency of mitotic and apoptotic cells in malignant melanoma and basal cell carcinoma. METHODS--Retrospective evaluation of haematoxylin and eosin stained slides fromExpand
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Plasma angiopoietin-2 (ANG2) as an angiogenic biomarker in renal cell carcinoma (RCC).
4630 Background: Several small molecules targeting angiogenic receptor tyrosine kinases (TKIs) are approved for treatment of advanced RCC. While many patients (pts) respond to TKIs, resistance deve...
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The human POLH gene is not mutated, and is expressed in a cohort of patients with basal or squamous cell carcinoma of the skin.
Skin cancer, the most common cancer in the general population, is strongly associated with exposure to the ultraviolet component of sunlight. To investigate the relationship between DNA damageExpand
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In situ end-labelling, light microscopic assessment and ultrastructure of apoptosis in lung carcinoma.
AIMS--To compare in situ end-labelling (ISEL) of apoptosis in lung carcinoma with quantitative and semiquantitative light microscopic assessment and ultrastructural observations. METHODS--ISEL ofExpand
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Abl expression in human fetal and adult tissues, tumours and tumour microvessels
Abl kinases encoded by the abl oncogenes inhibit apoptosis without affecting cell proliferation. The aim of this study was to examine a wide range of normal fetal and adult human tissues and aExpand
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Abstract #153: Cox-2 inhibition delays resistance to sunitinib in RCC xenograft models
Cox-2 inhibition delays resistance to sunitinib in RCC xenograft modelsBackground: Renal cell carcinoma (RCC) has been found to be responsive to agents that inhibit the vascular endothelial growthExpand
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