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Association of Hemolytic Activity of Pseudomonas entomophila, a Versatile Soil Bacterium, with Cyclic Lipopeptide Production
ABSTRACT Pseudomonas entomophila is an entomopathogenic bacterium that is able to infect and kill Drosophila melanogaster upon ingestion. Its genome sequence suggests that it is a versatile soilExpand
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Substitution of the Bordetella pertussis Lipid A Phosphate Groups with Glucosamine Is Required for Robust NF-κB Activation and Release of Proinflammatory Cytokines in Cells Expressing Human but Not
ABSTRACT Bordetella pertussis endotoxin is a key modulator of the host immune response, mainly due to the role of its lipid A moiety in Toll-like receptor 4 (TLR4)-mediated signaling. We haveExpand
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A secondary metabolite acting as a signalling molecule controls Pseudomonas entomophila virulence
Pseudomonas entomophila is an entomopathogenic bacterium that is lethal to Drosophila melanogaster within 1–2 days of ingestion of high doses. Flies orally infected with P. entomophila rapidlyExpand
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Biofilm-forming Pseudomonas aeruginosa bacteria undergo lipopolysaccharide structural modifications and induce enhanced inflammatory cytokine response in human monocytes
To determine whether growth of bacteria in biofilms triggers a specific immune response, we compared cytokine induction in human monocytes and mouse macrophages by planktonic and biofilm bacteria. WeExpand
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Microextraction of bacterial lipid A: easy and rapid method for mass spectrometric characterization Published, JLR Papers in Press, June 1, 2005. DOI 10.1194/jlr.D500014-JLR200
Endotoxins (lipopolysaccharides) are the main components of Gram-negative bacterial outer membranes. A quick and simple way to isolate their lipid region (lipid A) directly from whole bacterial cellsExpand
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Variability in the lipooligosaccharide structure and endotoxicity among Bordetella pertussis strains.
Bordetella endotoxins show remarkable structural variability both among each other and in comparison to other gram-negative bacteria. Here we demonstrate that, in contrast to the common BordetellaExpand
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Biofilms Formed by Gram-Negative Bacteria Undergo Increased Lipid A Palmitoylation, Enhancing In Vivo Survival
ABSTRACT Bacterial biofilm communities are associated with profound physiological changes that lead to novel properties compared to the properties of individual (planktonic) bacteria. The study ofExpand
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Minor Modifications to the Phosphate Groups and the C3′ Acyl Chain Length of Lipid A in Two Bordetella pertussis Strains, BP338 and 18-323, Independently Affect Toll-like Receptor 4 Protein
Background: Lipid A activation of TLR4 shapes immunity to Gram-negative bacteria. Results: In Bordetella pertussis lipid A, the genetic basis for longer C3′ acyl chains and glucosamine modificationExpand
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Structural characterization of Bordetella parapertussis lipid A Published, JLR Papers in Press, November 17, 2008.
Bordetella parapertussis like B. pertussis, is a causal agent of whooping cough but is not a strictly human pathogen. Because its endotoxin, a major structural component of the Gram-negative outerExpand
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Simple Method for Repurification of Endotoxins for Biological Use
ABSTRACT A method for obtaining highly purified endotoxin (lipopolysaccharide [LPS]) in a few hours by repurification of commercial or laboratory preparations was devised. It avoids the use ofExpand
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