• Publications
  • Influence
Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma.
It appears that IA-2 is a new member of the receptor-type PTP family that is expressed in islet and brain tissues that possesses highly conserved regions similar to the catalytic domains found in members of the protein tyrosine phosphatase (PTP) family. Expand
Isolation of a virus from the pancreas of a child with diabetic ketoacidosis.
Both the clinical picture and animal studies suggested that the patient's diabetes was virus induced. Expand
Immune interferon in the circulation of patients with autoimmune disease.
It is possible that the production of interferon may contribute to immunologic aberrations in auto-immune diseases and also protect the already compromised host from viral infections. Expand
Autoimmune type 1 diabetes: resolved and unresolved issues.
The demonstration of the presence of autoantibodies years before the onset of clinical symptoms has made it possible to identify individuals at high risk of developing type 1 diabetes and to initiate therapeutic intervention trials on relatively small numbers of subjects, suggesting that to a very large degree,type 1 diabetes is a predictable disease. Expand
IA-2, a transmembrane protein of the protein tyrosine phosphatase family, is a major autoantigen in insulin-dependent diabetes mellitus.
It is concluded that IA-2 is a major islet cell autoantigen in IDDM, and, together with GAD65, is responsible for much of the reactivity of ICA with pancreatic islets. Expand
Identification of a second transmembrane protein tyrosine phosphatase, IA-2beta, as an autoantigen in insulin-dependent diabetes mellitus: precursor of the 37-kDa tryptic fragment.
  • J. Lu, Q. Li, +5 authors M. Lan
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 19 March 1996
It is concluded that IA-2beta and IA- 2 are the precursors of the 37-kDa and 40-k da islet cell autoantigens, respectively, and that both IA-1 andIA-2 are major autoantigen in insulin-dependent diabetes mellitus. Expand
Virus-induced diabetes mellitus. XVIII. Inhibition by a nondiabetogenic variant of encephalomyocarditis virus
Co-infection experiments showed that the induction of diabetes by the D variant was inhibited by the B variant, and studies in animals showed that interferon appeared earlier and in greater amounts in the circulation of mice infected with the B as compared with the D variants. Expand
Decreased virulence of recombinant vaccinia virus expression vectors is associated with a thymidine kinase-negative phenotype
Experimental evidence is presented that thymidine kinase-negative (TK−) vaccinia virus recombinants, constructed by inserting a variety of DNA coding sequences into thevaccinia virus tk gene, are less pathogenic for mice than wild-type virus. Expand
Polyreactivity of antibody molecules.
  • A. Notkins
  • Biology, Medicine
  • Trends in immunology
  • 1 April 2004
It is argued that the best explanation for polyreactivity is that the antigen-binding ‘pocket' of many antibody molecules is more flexible than previously thought and can change conformation to accommodate different antigens. Expand