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Phagocytosis-independent antimicrobial activity of mast cells by means of extracellular trap formation.
These days it has been increasingly recognized that mast cells (MCs) are critical components of host defense against pathogens. In this study, we have provided the first evidence that MCs can killExpand
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Persistent elevation of high mobility group box-1 protein (HMGB1) in patients with severe sepsis and septic shock*
Objective:To study the systemic release and kinetics of high mobility group box-1 protein (HMGB1) in relation to clinical features in a population of patients with severe sepsis or septic shock andExpand
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An immunogenetic and molecular basis for differences in outcomes of invasive group A streptococcal infections
The role of host genetic factors in conferring predisposition or protection in infectious diseases has become evident. Infection with group A streptococci causes a wide spectrum of disease rangingExpand
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Genetic Relatedness and Superantigen Expression in Group A Streptococcus Serotype M1 Isolates from Patients with Severe and Nonsevere Invasive Diseases
ABSTRACT The relatedness of group A streptococcal (GAS) strains isolated from 35 Canadian patients with invasive disease of different severity was investigated by a variety of molecular methods. AllExpand
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M Protein, a Classical Bacterial Virulence Determinant, Forms Complexes with Fibrinogen that Induce Vascular Leakage
Increased vascular permeability is a key feature of inflammatory conditions. In severe infections, leakage of plasma from the vasculature induces a life-threatening hypotension. StreptococcusExpand
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Viable Group A Streptococci in Macrophages during Acute Soft Tissue Infection
Background Group A streptococcal severe soft tissue infections, such as necrotizing fasciitis, are rapidly progressive infections associated with high mortality. Group A streptococcus is typicallyExpand
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Inverse Relation between Disease Severity and Expression of the Streptococcal Cysteine Protease, SpeB, among Clonal M1T1 Isolates Recovered from Invasive Group A Streptococcal Infection Cases
ABSTRACT The streptococcal cysteine protease (SpeB) is one of the major virulence factors produced by group A streptococci (GAS). In this study we investigated if differences exist in SpeB productionExpand
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Pronounced elevation of resistin correlates with severity of disease in severe sepsis and septic shock
Objective:Resistin induces insulin resistance in mice. In humans, recent data suggest that resistin functions as a proinflammatory cytokine. Here, we studied resistin up to 2 wks after admission inExpand
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Inducible Cyclooxygenase Released Prostaglandin E2 Modulates the Severity of Infection Caused by Streptococcus pyogenes
Streptococcus pyogenes is a significant human pathogen that can cause life-threatening invasive infections. Understanding the mechanism of disease is crucial to the development of more effectiveExpand
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Coagulation, an ancestral serine protease cascade, exerts a novel function in early immune defense.
Phylogenetically conserved serine protease cascades play an important role in invertebrate and vertebrate immunity. The mammalian coagulation system can be traced back some 400 million years andExpand
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