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Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases.
TLDR
The cloning and recombinant expression of the two human UCKs will be important for development of novel pyrimidine ribonucleoside analogs and the characterization of their pharmacological activation.
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Conserved gene structure and transcription factor sites in the human and mouse deoxycytidine kinase genes 1
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Nucleotide affinity for a stable phosphorylated intermediate of nucleoside diphosphate kinase
TLDR
The true equilibrium dissociation constants of NDP for the analog of the phosphoenzyme are determined in the absence of phosphotransfer, allowing a better understanding of the catalytic mechanism of the enzyme.
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Pharmacokinetics of melphalan in isolated limb perfusion
TLDR
The pharmacokinetics of melphalan was studied by sampling of tissue and plasma in 72 rats that underwent isolated hyperthermic limb perfusion under different conditions and the highest tissue penetration was observed under the following conditions.
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