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An in silico model to predict the potential of dietary proteins as sources of dipeptidyl peptidase IV (DPP-IV) inhibitory peptides.
An in silico approach was developed to predict the potential of 72 dietary proteins to act as a source of dipeptidyl peptidase IV (DPP-IV) inhibitory peptides. The model takes 68 DPP-IV inhibitoryExpand
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Dipeptidyl peptidase IV inhibitory and antioxidative properties of milk protein-derived dipeptides and hydrolysates
Selected synthetic dipeptides and milk protein hydrolysates were evaluated for their dipeptidyl peptidase IV (DPP-IV) inhibitory properties, and their superoxide (SO) andExpand
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Inhibition of dipeptidyl peptidase IV and xanthine oxidase by amino acids and dipeptides.
Xanthine oxidase (XO) and dipeptidyl peptidase IV (DPP-IV) inhibition by amino acids and dipeptides was studied. Trp and Trp-containing dipeptides (Arg-Trp, Trp-Val, Val-Trp, Lys-Trp and Ile-Trp)Expand
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Inhibition of dipeptidyl peptidase IV (DPP-IV) by tryptophan containing dipeptides.
Twenty seven Trp containing dipeptides were evaluated for their ability to inhibit dipeptidyl peptidase IV (DPP-IV), a key enzyme involved in incretin hormone processing. Novel DPP-IV inhibitors wereExpand
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Dipeptidyl peptidase IV inhibitory properties of a whey protein hydrolysate: Influence of fractionation, stability to simulated gastrointestinal digestion and food–drug interaction
The in vitro dipeptidyl peptidase IV (DPP-IV) inhibitory activity of a whey protein hydrolysate (WPH) generated with a food-grade pancreatic enzyme preparation was studied. The 50% inhibitoryExpand
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Food protein hydrolysates as a source of dipeptidyl peptidase IV inhibitory peptides for the management of type 2 diabetes.
The prevalence of type 2 diabetes mellitus (T2DM) is increasing and it is estimated that by 2030 approximately 366 million people will be diagnosed with this condition. The use of dipeptidylExpand
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The scientific evidence for the role of milk protein-derived bioactive peptides in humans: a review
Abstract Milk proteins are a good source of bioactive peptides (BAPs). BAPs can positively affect various health biomarkers in vitro. The role of milk protein-derived BAPs in humans was reviewedExpand
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In silico approaches to predict the potential of milk protein-derived peptides as dipeptidyl peptidase IV (DPP-IV) inhibitors
Molecular docking of a library of all 8000 possible tripeptides to the active site of DPP-IV was used to determine their binding potential. A number of tripeptides were selected for experimentalExpand
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Strategies for the discovery, identification and validation of milk protein-derived bioactive peptides
Abstract Background The workflow used for the discovery of novel milk protein-derived bioactive peptides (BAPs) has significantly evolved over the past number of years. Many of the approachesExpand
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Biofunctional Properties of Caseinophosphopeptides in the Oral Cavity
Caseinophosphopeptides (CPPs), bioactive peptides released from caseins, have the ability to enhance bivalent mineral solubility. This is relevant to numerous biological functions in the oral cavityExpand
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