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Liquisolid technique for dissolution rate enhancement of a high dose water-insoluble drug (carbamazepine).
The results showed that the dissolution rate of liquisolid tablets was not significantly affected by storing the tablets at 25 degrees C/75% relative humidity for a period of 6 months, and the results of DSC and X-ray crystallography did not show any changes in crystallinity of the drug and interaction between carbamazepine and exipients during the process. Expand
The microsponge delivery system of benzoyl peroxide: preparation, characterization and release studies.
It was shown that the drug:polymer ratio, stirring rate, volume of dispersed phase influenced the particle size and drug release behavior of the formed microsponges and that the presence of emulsifier was essential for microsponge formation. Expand
Kinetic analysis of drug release from nanoparticles.
Considering the accuracy criteria the reciprocal powered time model could be suggested as a general model for analysis of multi mechanistic drug release from nanoparticles. Expand
Enhancement of dissolution rate of piroxicam using liquisolid compacts.
The results showed that liquisolid compacts demonstrated significantly higher drug release rates than those of conventionally made (capsules and directly compressed tablets containing micronized piroxicam) due to an increase in wetting properties and surface of drug available for dissolution. Expand
The influence of physical properties and morphology of crystallised lactose on delivery of salbutamol sulphate from dry powder inhalers.
It is proved that using binary combinations of solvents in crystallisation medium is vital in modification of the physicochemical and micromeritic properties of carriers to achieve a desirable aerosolisation performance from DPI formulations. Expand
The effect of penetration enhancers on drug delivery through skin: a QSAR study.
The structural requirements of penetration enhancers have been investigated using the Quantitative Structure-Activity Relationship (QSAR) technique and it was indicated that for 5-fluorouracil and diclofenac sodium, less hydrophobic enhancers were the most active. Expand
Liquisolid technique as a new approach to sustain propranolol hydrochloride release from tablet matrices.
Evidence is provided that polysorbate 80 (Tween 80) has important role in sustaining the release of drug from liquisolid matrices, and a reduction of T(g) of the polymer can be the reason for the release prolongation of liquislin tablets. Expand
An Investigation of Physicochemical Properties of Piroxicam Liquisolid Compacts
The results showed that enhanced dissolution rate of piroxicam liquisolid tablets was due to an increase in wetting properties and surface area of drug available for dissolution, and the effect of aging had no significant effect on hardness or dissolution profile of liqu isolid tablets. Expand
Dry powder inhalers: mechanistic evaluation of lactose formulations containing salbutamol sulphate.
The purpose of this study was to evaluate the relationships between physicochemical properties and aerosolisation performance of different grades of lactose. In order to get a wide range ofExpand
The effect of type and concentration of vehicles on the dissolution rate of a poorly soluble drug (indomethacin) from liquisolid compacts.
The liquisolid compacts technique can be a promising alternative for the formulation of water insoluble drugs, such as indomethacin into rapid release tablets. Expand