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DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses.
It is shown that DOCK8 is a Cdc42-specific guanine nucleotide exchange factor that is critical for interstitial DC migration, and that in the absence of Dock8, DCs failed to accumulate in the lymph node parenchyma for T-cell priming. Expand
The cell polarity protein mInsc regulates neutrophil chemotaxis via a noncanonical G protein signaling pathway.
During neutrophil chemotaxis via receptors coupled with the Gi family of heterotrimeric G proteins, directional movement is regulated by mInsc, a mammalian protein distantly related to the Drosophila polarity-organizer Inscuteable, which controls directional migration via noncanonical G protein signaling. Expand
Rab13 acts downstream of the kinase Mst1 to deliver the integrin LFA-1 to the cell surface for lymphocyte trafficking
A functional link between the small G protein Rab13 and Mst1 is found in lymphocyte adhesion and migration and suggests that Rab13 acts with Mst2 to regulate the spatial distribution of LFA-1 and the motility and trafficking of lymphocytes. Expand
Zizimin2: a novel, DOCK180‐related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes
- A. Nishikimi, N. Meller, N. Uekawa, K. Isobe, M. Schwartz, M. Maruyama
- Biology, Medicine
- FEBS letters
- 14 February 2005
The cloning of zizimin2 is reported, identified in a screen for genes enriched in germinal center B cells, which has similar primary structures and both proteins bound and activated CDC42 but not the Cdc42‐related proteins TC10 or TCL. Expand
DOCK5 functions as a key signaling adaptor that links FcεRI signals to microtubule dynamics during mast cell degranulation
- Kana Ogawa, Yoshihiko Tanaka, +8 authors Y. Fukui
- Biology, Medicine
- The Journal of experimental medicine
- 30 June 2014
DOCK5 is a key signaling adaptor that orchestrates remodeling of the microtubule network essential for mast cell degranulation.
Sequential Regulation of DOCK2 Dynamics by Two Phospholipids During Neutrophil Chemotaxis
During chemotaxis, activation of the small guanosine triphosphatase Rac is spatially regulated to organize the extension of membrane protrusions in the direction of migration. In neutrophils, Rac… Expand
DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis
- Y. Kunisaki, A. Nishikimi, +8 authors Y. Fukui
- Biology, Medicine
- The Journal of cell biology
- 28 August 2006
It is shown that during neutrophil chemotaxis DOCK2 regulates leading edge formation through PIP3-dependent membrane translocation and Rac activation, and it is found that Dock2 associates with PIP2 and translocates to the leading edge of chemotaxing neutrophils in a phosphatidylinositol 3-kinase (PI3K)–dependent manner. Expand
Localization of nitric oxide synthase activity in unfertilized oocytes and fertilized embryos during preimplantation development in mice.
Observations indicate that nitric oxide plays an important role as a diffusible regulator of cell proliferation and differentiation, especially at the developmental transition from the two-cell to the four-cell stage during preimplantation development of mice. Expand
Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2.
The identified 4-[3'-(2″-chlorophenyl)-2'-propen-1'-ylidene]-1-phenyl-3,5-pyrazolidinedione (CPYPP) as a small-molecule inhibitor of DOCK2 provides a rational of and a chemical scaffold for development of the Dock2-targeting immunosuppressant. Expand
T helper type 2 differentiation and intracellular trafficking of the interleukin 4 receptor-α subunit controlled by the Rac activator Dock2
Dock2 links T cell receptor signals to downregulation of IL-4Rα to control the lineage commitment of CD4+ T cells and causes allergic disease in mice lacking Dock2. Expand