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Potent bombesin-like peptides for GRP-receptor targeting of tumors with 99mTc: a preclinical study.
Four open chain tetraamine-functionalized bombesin (BB) analogues were synthesized [parent tetradecapeptide-based Demobesin 3 and 4 and BB(7-14)-based Demobesin 5 and 6]. Labeling with (99m)TcExpand
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Bombesin Receptor Antagonists May Be Preferable to Agonists for Tumor Targeting
Two bombesin analogs, Demobesin 4 and Demobesin 1, were characterized in vitro as gastrin-releasing peptide (GRP) receptor agonist and antagonist, respectively, and were compared as 99mTc-labeledExpand
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[99mTc]Demobesin 1, a novel potent bombesin analogue for GRP receptor-targeted tumour imaging
Abstract. Demobesin 1 is a potent new GRP-R-selective bombesin (BN) analogue containing an open chain tetraamine chelator for stable technetium-99m binding. Following a convenient labelling protocol,Expand
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Species differences of bombesin analog interactions with GRP-R define the choice of animal models in the development of GRP-R-targeting drugs.
UNLABELLED The biologic profiles of [(99m)Tc]Demobesin 1 ([(99m)Tc-N(4)(0-1),bzlg(0),d-Phe(6),Leu-NHEt(13),des-Met(14)]BB(6-14)) and [(111)In]Z-070 were compared using various gastrin-releasingExpand
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Radioiodinated metaiodobenzylguanidine (MIBG): radiochemistry, biology, and pharmacology.
As an analogue of adrenergic neurotransmitter norepinephrine (NE), metaiodobenzylguanidine (MIBG) demonstrates high uptake both in normal sympathetically innervated tissues, such as the heart andExpand
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JHU-2545 Selectively Shields Salivary Glands and Kidneys during PSMA-Targeted Radiotherapy
PURPOSE Prostate-specific membrane antigen (PSMA) radiotherapy is a promising treatment for metastatic castration-resistant prostate cancer (mCRPC) with several beta or alpha particle-emittingExpand
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[99mTc]Demotate, a new 99mTc-based [Tyr3]octreotate analogue for the detection of somatostatin receptor-positive tumours: synthesis and preclinical results
Abstract. Demotate is a new tetraamine-functionalised [Tyr3]octreotate derivative that binds technetium-99m with a high efficiency under mild conditions. The resulting radioligand, [99mTc]Demotate,Expand
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Trifunctional PSMA-targeting constructs for prostate cancer with unprecedented localization to LNCaP tumors
PurposeTreatment of late-stage prostate cancer by targeted radiotherapeutics such as 131I-MIP-1095 and 177Lu-PSMA-617 has shown encouraging early results. Lu-177 is preferred to I-131 in clinicalExpand
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TiO2/palygorskite composite nanocrystalline films prepared by surfactant templating route: synergistic effect to the photocatalytic degradation of an azo-dye in water.
Microfibrous palygorskite clay mineral and nanocrystalline TiO(2) are incorporating in the preparation of nanocomposite films on glass substrates via sol-gel route at 500°C. The synthesis involves aExpand
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99mTc targeting of Sst2-expressing tumors by tetraamineoctreotide: first results in CA20948 cells and rat models.
BACKGROUND Somatostatin subtype 2 receptor (sst2)-targeted tumor imaging with [(111)In-DTPA0]octreotide is an established method for scintigraphic detection of neuroendocrine tumors. [99mTc]DemotideExpand
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