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Colony-Stimulating Factor 1 Promotes Progression of Mammary Tumors to Malignancy
- E. Lin, A. Nguyen, R. Russell, J. Pollard
- Biology, Medicine
- The Journal of experimental medicine
- 19 March 2001
In human breast carcinomas, overexpression of the macrophage colony–stimulating factor (CSF-1) and its receptor (CSF-1R) correlates with poor prognosis. To establish if there is a causal relationship… Expand
Transforming growth factor beta3 induces cell death during the first stage of mammary gland involution.
Involution of the mammary gland following weaning is divided into two distinct phases. Initially, milk stasis results in the induction of local factors that cause apoptosis in the alveolar… Expand
The Macrophage Growth Factor CSF-1 in Mammary Gland Development and Tumor Progression
- E. Lin, V. Gouon-Evans, A. Nguyen, J. Pollard
- Medicine, Biology
- Journal of Mammary Gland Biology and Neoplasia
- 1 April 2002
Colony stimulating factor 1 (CSF-1), a major regulator of the mononuclear phagocytic lineage, is expressed in more than 70% of human breast cancers and its expression is correlated with poor… Expand
A novel mouse model of inflammatory bowel disease links mammalian target of rapamycin-dependent hyperproliferation of colonic epithelium to inflammation-associated tumorigenesis.
- Lin Deng, Jinfeng Zhou, +9 authors E. Lin
- Biology, Medicine
- The American journal of pathology
- 1 February 2010
Inflammatory bowel disease (IBD) is a high-risk condition for human colorectal cancer. However, our mechanistic understanding of the link between inflammation and tumorigenesis in the colon is… Expand
Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyperactivation of the Jak-2/STAT5a signaling cascade.
It is well established that mammary gland development and lactation are tightly controlled by prolactin signaling. Binding of prolactin to its cognate receptor (Prl-R) leads to activation of the… Expand
Treatment with rhenium-188-perrhenate and iodine-131 of NIS-expressing mammary cancer in a mouse model remarkably inhibited tumor growth.
- E. Dadachova, A. Nguyen, E. Lin, Leo Gnatovskiy, P. Lu, J. Pollard
- Nuclear medicine and biology
- 1 October 2005
INTRODUCTION Novel therapeutic modalities are needed for breast cancer patients in whom standard treatments are not effective. Mammary gland sodium/iodide symporter has been identified as a molecular… Expand
STAT3 in epithelial cells regulates inflammation and tumor progression to malignant state in colon.
Chronic inflammation is an important risk factor for the development of colorectal cancer; however, the mechanism of tumorigenesis especially tumor progression to malignancy in the inflamed colon is… Expand
STAT3 and sphingosine-1-phosphate in inflammation-associated colorectal cancer.
Accumulated evidences have demonstrated that signal transducer and activator of transcription 3 (STAT3) is a critical link between inflammation and cancer. Multiple studies have indicated that… Expand
Positron emission tomography agent 2-deoxy-2-[18F]fluoro-D-glucose has a therapeutic potential in breast cancer
BackgroundNovel approaches are needed for breast cancer patients in whom standard therapy is not effective. 2-Deoxy-2-[18F]fluoro-D-glucose (18F-FDG) was evaluated as a potential radiomolecular… Expand
The loss of STAT3 in mature osteoclasts has detrimental effects on bone structure
Signal Transducer and Activator of Transcription 3 (STAT3) has recently been shown to be involved in bone development and has been implicated in bone diseases, such as Job’s Syndrome. Bone growth and… Expand