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Frailty in older adults: evidence for a phenotype.
This study provides a potential standardized definition for frailty in community-dwelling older adults and offers concurrent and predictive validity for the definition, and finds that there is an intermediate stage identifying those at high risk of frailty. Expand
The Cardiovascular Health Study: design and rationale.
These examinations in CHS permit evaluation of CVD risk factors in older adults, particularly in groups previously under-represented in epidemiologic studies, such as women and the very old. Expand
Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health Study.
Findings are compatible with modest to moderate effects of sleep-disordered breathing on heterogeneous manifestations of CVD within a range of AHI values that are considered normal or only mildly elevated. Expand
Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia.
Sarcopenia should be considered in all older patients who present with observed declines in physical function, strength, or overall health, and patients who meet these criteria should further undergo body composition assessment using dual energy x-ray absorptiometry with sarcopenia being defined using currently validated definitions. Expand
Gait speed and survival in older adults.
In this pooled analysis of individual data from 9 selected cohorts, gait speed was associated with survival in older adults and predicted survival was as accurate as predicted based on age, sex, use of mobility aids, and self-reported function. Expand
The loss of skeletal muscle strength, mass, and quality in older adults: the health, aging and body composition study.
Although the loss of muscle mass is associated with the decline in strength in older adults, this strength decline is much more rapid than the concomitant loss of Muscle mass, suggesting a decline in muscle quality. Expand
Predictors of sleep-disordered breathing in community-dwelling adults: the Sleep Heart Health Study.
A significant proportion of occult SDB in the general population would be missed if screening or case finding were based solely on increased body habitus or male sex, particularly in older adults. Expand
Frailty: Emergence and Consequences in Women Aged 65 and Older in the Women's Health Initiative Observational Study
This work defines frailty using simple indicators and investigates the predictive validity of this frailty classification for death, hospitalization, hip fracture, and activity of daily living disability. Expand
Sarcopenia: Alternative Definitions and Associations with Lower Extremity Function
Objectives: To compare two sarcopenia definitions and examine the relationship between them and lower extrem‐ity function and other health related factors using data from the baseline examination ofExpand
Ankle brachial index combined with Framingham Risk Score to predict cardiovascular events and mortality: a meta-analysis.
Measurement of the ABI may improve the accuracy of cardiovascular risk prediction beyond the FRS, and is associated with approximately twice the 10-year total mortality, cardiovascular mortality, and major coronary event rate compared with the overall rate in each FRS category. Expand