A. Naya | Semantic Scholar

Design, synthesis, and discovery of a novel CCR1 antagonist.

A. Naya, Y. Sagara, N. Ohtake
Biology, Chemistry
Journal of medicinal chemistry
26 April 2001

This work has identified xanthene-9-carboxamide 1a, the first murine CCR1 receptor antagonist, which may be a useful tool for clarifying the role of C CR1 receptors in murine models of disease.

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Solanapyrones, Phytotoxins Produced by Alternaria solani: Biosynthesis and Isolation of Minor Components.

H. Oikawa, T. Yokota, C. Sakano, Y. Suzuki, A. Naya, A. Ichihara
Chemistry
Bioscience, biotechnology, and biochemistry
23 October 1998

The phytotoxicity of solanapyrones on lettuce seedlings is discussed and feeding experiments with various isotopically labeled acetates and methionine established the biosynthetic pathway of solAnapyrones.

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Structure-activity relationships of 2-(benzothiazolylthio)acetamide class of CCR3 selective antagonist.

A. Naya, Kensuke Kobayashi, N. Ohtake
Chemistry
Chemical & pharmaceutical bulletin
1 June 2003

Derivatization of 1a including incorporation of substituent(s) into each benzene ring of the benzothiazole and piperidine side chain resulted in the identification of potent and selective compounds exhibiting nano-molar binding affinity and greater than 800-fold selectivity for the CCR3 receptor over the C CR1 receptor.

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CCR1 chemokine receptor antagonist.

T. Saeki, A. Naya
Biology, Medicine
Current pharmaceutical design
31 May 2003

The biology and pathophysiology of CCR1, and some of its currently reported antagonists, are highlighted and their pharmacological effects have recently been disclosed.

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Identification of a potent and nonpeptidyl ccr3 antagonist.

T. Saeki, K. Ohwaki, K. Noguchi
Biology, Chemistry
Biochemical and biophysical research…
2 March 2001

It is suggested that Compound X may be a useful tool for elucidating the pathophysiological roles of CCR3 in a variety of allergic disorders.

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Effect of hibernation, thyroid hormones and dexamethasone on cytosolic and mitochondrial glycerol-3-phosphate dehydrogenase from jerboa (Jaculus orientalis).

W. Berrada, A. Naya, L. Ouafik, N. Bourhim
Biology
Comparative biochemistry and physiology. Part B…
1 April 2000

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Structure-activity relationships of xanthene carboxamides, novel CCR1 receptor antagonists.

A. Naya, M. Ishikawa, N. Ohtake
Chemistry, Biology
Bioorganic & medicinal chemistry
1 March 2003

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Discovery of a novel CCR3 selective antagonist.

A. Naya, K. Kobayashi, N. Ohtake
Chemistry, Biology
Bioorganic & medicinal chemistry letters
7 May 2001

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First Direct Evidence in Biological Diels-Alder Reaction of Incorporation of Diene-Dienophile Precursors in the Biosynthesis of Solanapyrones

H. Oikawa, Yuichi Suzuki, A. Naya, K. Katayama, A. Ichihara
Chemistry
1 April 1994

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Involvement of Diels–Alder reactions in the biosynthesis of secondary natural products: the late stage of the biosynthesis of the phytotoxins solanapyrones

H. Oikawa, Yuichi Suzuki, K. Katayama, A. Naya, C. Sakano, A. Ichihara
Chemistry, Biology
1999

The results strongly support the involvement of a Diels–Alder reaction in the biosynthesis of solanapyrones and the first example of intact incorporation of diene-dienophile precursors into natural [4 + 2] adducts.

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