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Design, synthesis, and discovery of a novel CCR1 antagonist.
This work has identified xanthene-9-carboxamide 1a, the first murine CCR1 receptor antagonist, which may be a useful tool for clarifying the role of C CR1 receptors in murine models of disease.
Solanapyrones, Phytotoxins Produced by Alternaria solani: Biosynthesis and Isolation of Minor Components.
- H. Oikawa, T. Yokota, C. Sakano, Y. Suzuki, A. Naya, A. Ichihara
- ChemistryBioscience, biotechnology, and biochemistry
- 23 October 1998
The phytotoxicity of solanapyrones on lettuce seedlings is discussed and feeding experiments with various isotopically labeled acetates and methionine established the biosynthetic pathway of solAnapyrones.
Structure-activity relationships of 2-(benzothiazolylthio)acetamide class of CCR3 selective antagonist.
Derivatization of 1a including incorporation of substituent(s) into each benzene ring of the benzothiazole and piperidine side chain resulted in the identification of potent and selective compounds exhibiting nano-molar binding affinity and greater than 800-fold selectivity for the CCR3 receptor over the C CR1 receptor.
CCR1 chemokine receptor antagonist.
The biology and pathophysiology of CCR1, and some of its currently reported antagonists, are highlighted and their pharmacological effects have recently been disclosed.
Identification of a potent and nonpeptidyl ccr3 antagonist.
It is suggested that Compound X may be a useful tool for elucidating the pathophysiological roles of CCR3 in a variety of allergic disorders.
Effect of hibernation, thyroid hormones and dexamethasone on cytosolic and mitochondrial glycerol-3-phosphate dehydrogenase from jerboa (Jaculus orientalis).
Structure-activity relationships of xanthene carboxamides, novel CCR1 receptor antagonists.
Discovery of a novel CCR3 selective antagonist.
First Direct Evidence in Biological Diels-Alder Reaction of Incorporation of Diene-Dienophile Precursors in the Biosynthesis of Solanapyrones
Involvement of Diels–Alder reactions in the biosynthesis of secondary natural products: the late stage of the biosynthesis of the phytotoxins solanapyrones
The results strongly support the involvement of a Diels–Alder reaction in the biosynthesis of solanapyrones and the first example of intact incorporation of diene-dienophile precursors into natural [4 + 2] adducts.