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Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells.
The wealth of knowledge currently available that best explains the formation of these important nuclear anomalies that are commonly seen in cancer and are indicative of genome damage events that could increase the risk of developmental and degenerative diseases are summarized. Expand
IPCS guidelines for the monitoring of genotoxic effects of carcinogens in humans. International Programme on Chemical Safety.
The most often studied genotoxicity endpoints have been selected and they are structural and numerical chromosomal aberrations assessed using cytogenetic methods, DNA damage assessed using bio-chemical/electrophoretic assays or sister chromatid exchanges, and hypoxanthine-guanine phosphoribosyltransferase (HPRT) mutations. Expand
The genetic defect in Cockayne syndrome is associated with a defect in repair of UV-induced DNA damage in transcriptionally active DNA.
The results have implications for understanding the pleiotropic clinical effects associated with disorders having defects in the repair of DNA damage, and in particular, neurodegeneration appears to be associated with the loss of preferential repair of active genes and is not simply correlated with reduced levels of overall repair. Expand
A unique metabolism of inorganic arsenic in native Andean women.
The metabolism of inorganic arsenic (As) in native women in four Andean villages in north-western Argentina with elevated levels of As in the drinking water has been investigated, and arsenic was excreted in the urine mainly as inorganic As and DMA. Expand
Xeroderma pigmentosum complementation group C cells remove pyrimidine dimers selectively from the transcribed strand of active genes.
Using strand-specific probes, it is shown that in normal cells, preferential repair of the 5' part of the ADA gene is due to the rapid and efficient Repair of the transcribed strand, and in XP-C cells, the nontranscribed strand is not repaired significantly. Expand
  • A. Natarajan
  • Medicine
  • Cytogenetic and Genome Research
  • 26 August 1998
SCE increased at all the tested concentrations except the lowest dose, while that low dose induced a significant effect on the induction of chromosomal aberrations in the germ cells, indicating that rifampicin has a potential clastogenic effect. Expand
Genotoxic effects of occupational exposure to lead and cadmium.
It is indicated that lead and cadmium induce clastogenic as well as aneugenic effects in peripheral lymphocytes, indicating a potential health risk for working populations with significant exposures to these heavy metals. Expand
The residual repair capacity of xeroderma pigmentosum complementation group C fibroblasts is highly specific for transcriptionally active DNA.
The findings suggest the existence of two independently operating pathways directed towards repair of pyrimidine dimers in either active or inactive chromatin in normal fibroblasts. Expand
Deficient repair of the transcribed strand of active genes in Cockayne's syndrome cells.
The results support the model that CS cells lack a factor which is involved in targeting repair enzymes specifically towards DNA damage located in (potentially) active DNA. Expand
Chromosomal aberrations: formation, identification and distribution.
The method of fluorescence in situ hybridisation (FISH) has uncovered unexpected complexities of CA and this will lead to changes in thinking about the origin of CA. Expand