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Epithelial-mesenchymal transition mediated tumourigenesis in the gastrointestinal tract.
TLDR
Regulators of EMT may provide novel clinical targets to detect GI cancers early, so that cancers previously associated with a poor prognosis such as pancreatic cancer can be diagnosed before they become inoperable. Expand
Apolipoprotein E allele 4 is not a sufficient or a necessary predictor of the development of Mild Cognitive Impairment
TLDR
The apoE ε4 genotype is not a necessary or sufficient risk factor for MCI and further studies need to investigate the influence of the whole range of genetic and environmental risk factors on the course of Alzheimer's disease. Expand
Reasons for Hospital Admissions in Dementia Patients in Birmingham, UK, during 2002–2007
TLDR
Dementia patients are frequently admitted as emergency cases, but dementia itself is often not the primary diagnosis, so earlier detection of the specific conditions mentioned above may reduce emergency hospital admissions amongst dementia patients. Expand
Type-2 diabetes mellitus in schizophrenia: Increased prevalence and major risk factor of excess mortality in a naturalistic 7-year follow-up
TLDR
Schizophrenics have more and additionally suffer more from diabetes: co-morbidity with diabetes mellitus is increased in schizophrenia in comparison with hospital controls; type 2abetes mellitus causes significant excess mortality in schizophrenia. Expand
Alzheimer's Disease and Co-Morbidity: Increased Prevalence and Possible Risk Factors of Excess Mortality in a Naturalistic 7-Year Follow-Up
TLDR
Patients with AD have a different pattern of co-morbidity, but die from the same diseases as other hospitalized patients, and preventive measures may be helpful to reduce the high risk and fatal consequences of undetected disease in AD. Expand
Alzheimer ’ s disease and comorbidity : Increased prevalence and possible risk factors of excess mortality in a naturalistic 7-year follow-up
Background. – Subjects with late-onset Alzheimer’s disease (AD) have to be sufficiently healthy to live long enough to experience and to be diagnosed with dementia in later life. In contrast,Expand
The burden of cardiovascular disease amongst psychiatric patients.
Engineering synucleinopathy‐resistant human dopaminergic neurons by CRISPR‐mediated deletion of the SNCA gene
TLDR
This work demonstrates that reducing or completely removing SNCA alleles by CRISPR/Cas9n‐mediated gene editing confers a measure of resistance to Lewy pathology. Expand
Preparation, characterization, and banking of clinical-grade cells for neural transplantation: Scale up, fingerprinting, and genomic stability of stem cell lines.
TLDR
The challenge now is to apply Good Manufacturing Practice (GMP) to the academic discoveries and protocols to produce clinical-grade transplantable mDA cells from human embryonic stem cells and induced pluripotent stem cells. Expand
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