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BDNF-induced TrkB activation down-regulates the K+–Cl− cotransporter KCC2 and impairs neuronal Cl− extrusion
Pathophysiological activity and various kinds of traumatic insults are known to have deleterious long-term effects on neuronal Cl− regulation, which can lead to a suppression of fast postsynapticExpand
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Seizures induce widespread upregulation of cystatin B, the gene mutated in progressive myoclonus epilepsy, in rat forebrain neurons
Loss of function mutations in the gene encoding the cysteine protease inhibitor, cystatin B (CSTB), are responsible for the primary defect in human progressive myoclonus epilepsy (EPM1). CSTBExpand
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Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures.
Neuronal apoptosis was observed in the rat dentate gyrus in two experimental models of human limbic epilepsy. Five hours after one hippocampal kindling stimulation, a marked increase of in situExpand
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GDNF family ligands and receptors are differentially regulated after brain insults in the rat
Expression of mRNAs for glial cell line‐derived neurotrophic factor (GDNF), neurturin (NTN) and their receptors was studied in adult rat brain using in situ hybridization after 40 kindling‐evoked,Expand
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Environment Matters: Synaptic Properties of Neurons Born in the Epileptic Adult Brain Develop to Reduce Excitability
Neural progenitors in the adult dentate gyrus continuously produce new functional granule cells. Here we used whole-cell patch-clamp recordings to explore whether a pathological environmentExpand
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Evidence for Neuroprotective Effects of Endogenous Brain-Derived Neurotrophic Factor after Global Forebrain Ischemia in Rats
The levels of brain-derived neurotrophic factor (BDNF) vary between different forebrain areas and show region-specific changes after cerebral ischemia. The present study explores the possibility thatExpand
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Differential suppression of seizures via Y2 and Y5 neuropeptide Y receptors
Neuropeptide Y (NPY) prominently inhibits epileptic seizures in different animal models. The NPY receptors mediating this effect remain controversial partially due to lack of highly selectiveExpand
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Suppression of limbic motor seizures by electrical stimulation in thalamic reticular nucleus
Kindling is a model of temporal lobe epilepsy in which repeated electrical stimulations in limbic areas lead to progressive increase of seizure susceptibility, culminating in generalized convulsionsExpand
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Basal forebrain neurons suppress amygdala kindling via cortical but not hippocampal cholinergic projections in rats
Intraventricular administration of the immunotoxin 192 IgG‐saporin in rats has been shown to cause a selective loss of cholinergic afferents to the hippocampus and cortical areas, and to facilitateExpand
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Suppressed kindling epileptogenesis in mice with ectopic overexpression of galanin
The neuropeptide galanin has been shown to suppress epileptic seizures. In cortical and hippocampal areas, galanin is normally mainly expressed in noradrenergic afferents. We have generated a mouseExpand
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