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Fast Dissolving Curcumin Cocrystals
Curcumin is the principal curcuminoid of the popular Indian spice turmeric. Despite the diverse pharmacological activities of this bioactive phenol, its application as a drug is severely limited by…
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Solubility Advantage of Amorphous Drugs and Pharmaceutical Cocrystals
The current phase of drug development is witnessing an oncoming crisis due to the combined effects of increasing R&D costs, decreasing number of new drug molecules being launched, several blockbuster…
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C−H···F Interactions in the Crystal Structures of Some Fluorobenzenes
The existence and nature of C−H···F−C interactions in crystalline fluorobenzenes 1−3 and 7−10 are discussed. These compounds were chosen because they contain only C, H, and F atoms; this is necessary…
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Novel furosemide cocrystals and selection of high solubility drug forms.
TLDR
Furosemide was screened in cocrystallization experiments with pharmaceutically acceptable coformer molecules to discover cocrystals of improved physicochemical properties, that is high solubility and good stability, that are identified in a solid form screen.
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Eutectics as improved pharmaceutical materials: design, properties and characterization.
TLDR
The same crystal engineering principles which have been profitably utilized for cocrystal design in the past decade can now be applied to make eutectics as novel composite materials, illustrated by stable eutECTics of the hygroscopic salt of the anti-tuberculosis drug ethambutol as a case study.
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A novel curcumin–artemisinin coamorphous solid: physical properties and pharmacokinetic profile
TLDR
PXRD and FESEM analysis explains the molecular basis for the solubility enhancement of coamorphous CUR–ART and a dramatic increase in the pharmacokinetic profile of curcumin is reported.
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Pharmaceutical cocrystals: walking the talk.
TLDR
Some prominent examples of drug cocrystals which exhibit variable hardness/softness and elasticity/plasticity depending on coformer selection, improvement of solubility and permeability in the same cocrystal, increase of the melting point for solid formulation, enhanced color performance, photostability and hydration stability, and a longer half-life are highlighted.
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Enhanced Bioavailability in the Oxalate Salt of the Anti-Tuberculosis Drug Ethionamide
Ethionamide (ETH) is an anti-tuberculosis (TB) Biopharmaceutics Classification System class II drug of poor aqueous solubility. The objective of the present study was to evaluate the solubility and…
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Tetramorphs of the Antibiotic Drug Trimethoprim: Characterization and Stability
Trimethoprim (TMP) is a well-known antifolate drug and one of the most widely used broad-spectrum antibiotics. TMP was first approved by the United States FDA in combination with sulfamethoxazole…
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Pharmaceutical Cocrystals of Niclosamide
Niclosamide (NCL) is an anthelmintic BCS class II drug of low solubility and high permeability. Pharmaceutical cocrystals of NCL were prepared with GRAS molecules, such as caffeine (CAF), urea (URE),…
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