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Amyloid-β, tau, and the cholinergic system in Alzheimer’s disease: seeking direction in a tangle of clues
TLDR
None of the popular hypotheses of AD such as amyloidopathy or tauopathy seem to be responsible for the changes observed in AD alone, so the main culprit should be sought higher in the stream somewhere in APP metabolism or Wnt signaling in the cholinergic system of the basal forebrain.
Apoptosis and Caspase 3 Pathway Role on Anti-Proliferative Effects of Scrophulariaoxy Sepala Methanolic Extract on Caco-2 Cells.
TLDR
The methanolic extract of SO showed inhibitory effect on Caco-2 cells and induced apoptosis in a dose-dependent manner comparable to cisplatin and higher than capecitabine 2 commonly used chemotherapeutic agent for various cancers.
Identification and characterization of a Streptomyces sp. isolate exhibiting activity against multidrug-resistant coagulase-negative Staphylococci
TLDR
The diethyl ether extracted metabolite of the new Streptomyces sp.
Anti-tumor Effect of Quercetin Loaded Chitosan Nanoparticles on Induced Colon Cancer in Wistar Rats
TLDR
Investigating the site-specific drug delivery of 5-FU with chitosan (CS) as a carrier and quercetin (Qu) against induced colon cancer in Wistar rats proved that the NPs could have promising results in site- specific and sustained drug delivery against colorectal cancer.
Effect of Hypericum perforatum aqueous extract on formalin induced pain and inflammation in mice
Hypericum perforatum is a medicinal plant species containing many polyphenolic compounds, specially flavonoids and phenolic acids. A number of studies have shown that polyphenolic compounds have high
STUDY OF BCL2 PROTEIN EXPRESSION IN EXPERIMENTAL COLON CARCINOMA FOLLOWING EFFECTS OF CALENDULA OFFICINALIS IN RATS
TLDR
This in-vivo study indicated that BCL2 protein expression decreases in aberrant crypt foci epithelial cells of experimental colorectal carcinoma in rats following orally administration of Calendula officinalis extract.
A Visualized Guideline for Cancer Chemotherapy Induced Neuropathic Pain in Mice Using Cisplatin
TLDR
Different steps, considerations and approaches including cisPlatin intravenous injection as well as behavioral assessment of cisplatin sensory neuropathy are explained in this paper.
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