A. Nadzan

Publications123
h-index28
Citations2,556
Highly Influential Citations67
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Design and Synthesis of Potent Retinoid X Receptor Selective Ligands that Induce Apoptosis in Leukemia Cells.
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Structural identification of the major DNA adduct formed by aflatoxin B1 in vitro.
The covalent binding of the hepatocarcinogen aflatoxin B1 by rat liver microsomes to calf thymus DNA resulted in a binding level equal to one aflatoxin residue per 60 DNA nucleotides. An aflatoxin… Expand
  • 418
  • 11
Activation of specific RXR heterodimers by an antagonist of RXR homodimers
RETINOID X receptor (RXR) plays a central role in the regulation of many intracellular receptor signalling pathways1 and can mediate ligand-dependent transcription, acting as a homodimer or as a… Expand
  • 152
  • 11
Malonyl Coenzyme A Decarboxylase Inhibition Protects the Ischemic Heart by Inhibiting Fatty Acid Oxidation and Stimulating Glucose Oxidation
Abnormally high rates of fatty acid oxidation and low rates of glucose oxidation are important contributors to the severity of ischemic heart disease. Malonyl coenzyme A (CoA) regulates fatty acid… Expand
  • 186
  • 7
Matrix metalloproteinase inhibitors: a structure-activity study.
Modifications around the dipeptide-mimetic core of a hydroxamic acid based matrix metalloproteinase inhibitor were studied. These variations incorporated a variety of natural, unnatural, and… Expand
  • 128
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Synthesis and structure-activity relationship of small-molecule malonyl coenzyme A decarboxylase inhibitors.
The discovery and structure-activity relationship of first-generation small-molecule malonyl-CoA decarboxylase (MCD; CoA = coenzyme A) inhibitors are reported. We demonstrated that MCD inhibitors… Expand
  • 32
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Novel nonsecosteroidal vitamin D mimics exert VDR-modulating activities with less calcium mobilization than 1,25-dihydroxyvitamin D3.
BACKGROUND The secosteroid 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) acts through the vitamin D receptor (VDR) to elicit many activities that make it a promising drug candidate for the treatment of a… Expand
  • 129
  • 3
Identification of the first retinoid X, receptor homodimer antagonist.
  • 48
  • 3
Synthesis of retinoid X receptor-specific ligands that are potent inducers of adipogenesis in 3T3-L1 cells.
A novel series of oxime ligands has been synthesized that displays potent, specific activation of the retinoid X receptors (RXRs). The oximes of 3-substituted… Expand
  • 57
  • 2
Hybrid cholecystokinin (CCK) antagonists: new implications in the design and modification of CCK antagonists.
  • 31
  • 2