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Nuclear Melatonin Receptors
Current opinions on the potential role of orphan nuclear retinoid receptors of the ROR/RZR subfamily in regulatory activities of the pineal gland hormone melatonin are reviewed. The mechanisms ofExpand
Nuclear Receptors: Nomenclature, Ligands, Mechanisms of Their Effects on Gene Expression
  • A. N. Smirnov
  • Biology, Medicine
  • Biochemistry (Moscow)
  • 1 September 2002
Nuclear receptors are DNA binding transcription factors possessing conservative domain organization. Their activity is regulated by lipophilic ligands, phosphorylation, and by interactions with otherExpand
Effect of sex hormones on levels of mRNAs coding for proteins involved in lipid metabolism in macrophages
The effects of sex hormones estradiol (E2), testosterone (Te), and 5α-dihydrotestosterone (DT) on cholesterol accumulation induced by modified low density lipoproteins (LDL) in macrophagesExpand
Lipid Regulators during Atherogenesis: Expression of LXR, PPAR, and SREBP mRNA in the Human Aorta
Transcription factors LXRs, PPARs, and SREBPs have been implicated in a multitude of physiological and pathological processes including atherogenesis. However, little is known about the regulation ofExpand
The size and/or configuration of the cycloalkane D′ ring in pentacyclic progesterone derivatives are crucial for their high-affinity binding to a protein in addition to progesterone receptor in rat
[(3)H]labeled progesterone and a number of its 16alpha, 17alpha-cycloalkano derivatives with an additional three to six-membered D' ring were investigated for mutual competition and equilibriumExpand
Synthesis of tritium‐labelled biologically active analogues of progesterone by selective hydrogenation of 16α,17α‐cyclohex‐3′‐en‐pregna‐1,4‐dien‐3,20‐dione
The procedure of selective hydrogenation with gaseous tritium of 16α,17α-cyclohex-3'-en-pregna-1,4-dien-3,20-dione (StO) has been elaborated, and isotopically labelledExpand
3- and 19-Oximes of 16α,17α-cyclohexanoprogesterone derivatives: Synthesis and interactions with progesterone receptor and other proteins
Series of 3- and 19-oximes of 16alpha,17alpha-cyclohexanoprogesterone derivatives (pregna-d'-pentaranes) have been synthesized with the aim of probing the surfaces of progesterone receptor's and twoExpand
Activity of 2-aryl-2-(3-indolyl)acetohydroxamates against drug-resistant cancer cells.
Many types of tumor, including glioma, melanoma, non-small cell lung, esophageal, and head and neck cancer, among others, are intrinsically resistant to apoptosis induction and poorly responsive toExpand