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- Publications
- Influence
Widespread transmission of independent cancer lineages within multiple bivalve species
- M. Metzger, A. Villalba, +6 authors S. Goff
- Biology, Medicine
- Nature
- 5 June 2016
Most cancers arise from oncogenic changes in the genomes of somatic cells, and while the cells may migrate by metastasis, they remain within that single individual. Natural transmission of cancer… Expand
Identification and phylogenetic comparison of p53 in two distinct mussel species (Mytilus).
- A. Muttray, R. L. Cox, S. St-Jean, P. van Poppelen, C. Reinisch, S. A. Baldwin
- Biology, Medicine
- Comparative biochemistry and physiology…
- 1 February 2005
The extent to which humans and wildlife are exposed to anthropogenic challenges is an important focus of environmental research. Potential use of p53 gene family marker(s) for aquatic environmental… Expand
Population dynamics and metabolic activity of Pseudomonas abietaniphila BKME-9 within pulp mill wastewater microbial communities assayed by competitive PCR and RT-PCR
- A. Muttray, Zhontang Yu, W. Mohn
- Biology
- 1 December 2001
Resin acids contribute to the acute toxicity of pulp and paper mill effluent. We monitored the abundance and metabolic activity of the resin acid degrader, Pseudomonas abietaniphila BKME-9, within… Expand
Activation of transcription and retrotransposition of a novel retroelement, Steamer, in neoplastic hemocytes of the mollusk Mya arenaria
- G. Arriagada, M. Metzger, +5 authors S. Goff
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 8 September 2014
Significance The soft shell clam in many areas of the North Atlantic is afflicted with a fatal leukemia-like disease of unknown origin. Leukemic cells from the diseased animals were found to release… Expand
Identification of DeltaN Isoform and Polyadenylation Site Choice Variants in Molluscan p63/p73-Like Homologues
- A. Muttray, R. L. Cox, C. Reinisch, S. A. Baldwin
- Biology, Medicine
- Marine Biotechnology
- 22 January 2007
The p53 family of transcription factors has been implicated in many vertebrate cancers. Altered p53 and p73 protein expression observed in leukemic cells of molluscs suggests that these transcription… Expand
Invertebrate p53-like mRNA isoforms are differentially expressed in mussel haemic neoplasia.
- A. Muttray, P. Schulte, S. A. Baldwin
- Biology, Medicine
- Marine environmental research
- 1 October 2008
Mussels of the genus Mytilus are widely used in environmental monitoring. They can develop a leukaemia-like disease, haemic neoplasia, which could be induced, in part, by environmental stressors. The… Expand
RNA/DNA ratio as an indicator of metabolic activity in resin acid-degrading bacteria
- A. Muttray, W. Mohn
- Biology
- 1998
We investigated the relationship between the growth rate and the ratio of RNA to DNA in of four resin acid degrading bacteria isolated from a sequencing batch reactor (SBR). Chemical assays as well… Expand
Variations in p53-like cDNA sequence are correlated with mussel haemic neoplasia: A potential molecular-level tool for biomonitoring.
- Ekaterina I Vassilenko, A. Muttray, P. Schulte, S. A. Baldwin
- Biology, Medicine
- Mutation research
- 30 August 2010
Several bivalve species, including mussels (Mytilus spp.) and clams (Mya spp.), are susceptible to a leukemia-like disease called haemic neoplasia that has been known to decimate whole populations.… Expand
A single clonal lineage of transmissible cancer identified in two marine mussel species in South America and Europe
- Marisa A Yonemitsu, Rachael M. Giersch, +16 authors M. Metzger
- Biology, Medicine
- eLife
- 5 November 2019
Transmissible cancers, in which cancer cells themselves act as an infectious agent, have been identified in Tasmanian devils, dogs, and four bivalves. We investigated a disseminated neoplasia… Expand
Low Variation in a Y-Chromosomal Growth Hormone Pseudogene Relative to its Functional Autosomal Progenitor Gene in Chinook Salmon
- A. Muttray, D. Sakhrani, R. Withler, R. Devlin
- Biology
- 17 August 2015
AbstractMost fish species do not have single-chromosome-based sex determination or display cytologically distinguishable sex chromosomes. The selective forces acting on homologous sequences in… Expand