• Publications
  • Influence
The biochemistry of peroxisomal β-oxidation in the yeast Saccharomyces cerevisiae
Peroxisomal fatty acid degradation in the yeast Saccharomyces cerevisiae requires an array of β-oxidation enzyme activities as well as a set of auxiliary activities to provide the β-oxidationExpand
  • 241
  • 10
The biochemistry of peroxisomal beta-oxidation in the yeast Saccharomyces cerevisiae.
Peroxisomal fatty acid degradation in the yeast Saccharomyces cerevisiae requires an array of beta-oxidation enzyme activities as well as a set of auxiliary activities to provide the beta-oxidationExpand
  • 90
  • 10
The 1.3 A crystal structure of human mitochondrial Delta3-Delta2-enoyl-CoA isomerase shows a novel mode of binding for the fatty acyl group.
The crystal structure of Delta3-Delta2-enoyl-CoA isomerase from human mitochondria (hmEci), complexed with the substrate analogue octanoyl-CoA, has been refined at 1.3 A resolution. This enzyme takesExpand
  • 42
  • 3
The Crystal Structure of 3 - 2 -Enoyl-CoA Isomerase
The active-site geometry of the first crystal structure of a 3 - 2 -enoylcoenzyme A (CoA) isomerase (the peroxisomal enzyme from the yeast Saccharomyces cerevisiae) shows that only one catalyticExpand
  • 11
  • 2
The crystal structure of delta(3)-delta(2)-enoyl-CoA isomerase.
The active-site geometry of the first crystal structure of a Delta(3)-Delta(2)-enoyl-coenzyme A (CoA) isomerase (the peroxisomal enzyme from the yeast Saccharomyces cerevisiae) shows that only oneExpand
  • 32
  • 1
  • PDF
Evaluating university-industry collaboration: the European Foundation of Quality Management excellence model-based evaluation of university-industry collaboration
The growth in university-industry collaboration has resulted in an increasing demand for methods to evaluate it. This paper presents one way to evaluate an organization’s collaborative activitiesExpand
  • 11
  • 1
  • PDF
Structural studies on Δ3‐Δ2‐enoyl‐CoA isomerase: the variable mode of assembly of the trimeric disks of the crotonase superfamily
Subunits of the enzymes in the crotonase superfamily form tight trimeric disks. In most members of this protein superfamily these disks assemble further into hexamers. Here we report on the 2.1 ÅExpand
  • 24
Peroxisomal D 3-cisD 2-trans-Enoyl-CoA Isomerase Encoded by ECI 1 Is Required for Growth of the Yeast Saccharomyces cerevisiae on Unsaturated Fatty Acids
We have identified the Saccharomyces cerevisiae gene ECI1 encoding D-cis-D-trans-enoyl-CoA isomerase that acts as an auxiliary enzyme in the b-oxidation of (poly)unsaturated fatty acids. A mutantExpand
  • 6
  • PDF
Alternatives to the isomerase-dependent pathway for the beta-oxidation of oleic acid are dispensable in Saccharomyces cerevisiae. Identification of YOR180c/DCI1 encoding peroxisomal
Fatty acids with double bonds at odd-numbered positions such as oleic acid can enter beta-oxidation via a pathway relying solely on the auxiliary enzyme Delta(3)-Delta(2)-enoyl-CoA isomerase, termedExpand
  • 9
Peroxisomal Delta3-cis-Delta2-trans-enoyl-CoA isomerase encoded by ECI1 is required for growth of the yeast Saccharomyces cerevisiae on unsaturated fatty acids.
We have identified the Saccharomyces cerevisiae gene ECI1 encoding Delta3-cis-Delta2-trans-enoyl-CoA isomerase that acts as an auxiliary enzyme in the beta-oxidation of (poly)unsaturated fatty acids.Expand
  • 10