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A voxel-based investigation of brain structure in male adolescents with autistic spectrum disorder
We report a voxel-based morphometric whole brain analysis, using a group specific template, on 16 individuals of normal intelligence with autistic spectrum disorder (ASD), and a group of 16 age-, sex- and IQ-matched controls. Expand
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function
General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENTExpand
Tau aggregation inhibitor therapy: an exploratory phase 2 study in mild or moderate Alzheimer's disease.
BACKGROUND As tau aggregation pathology correlates with clinical dementia in Alzheimer's disease (AD), a tau aggregation inhibitor (TAI) could have therapeutic utility. Methylthioninium (MT) acts asExpand
Childhood socioeconomic status and adult brain size: Childhood socioeconomic status influences adult hippocampal size
To investigate in older adults without dementia the relationships between socioeconomic status (SES) in childhood and magnetic resonance imaging (MRI)‐derived brain volume measures typical of brainExpand
Brain white matter hyperintensities: relative importance of vascular risk factors in nondemented elderly people.
PURPOSE To prospectively determine whether there is an association between brain white matter signal hyperintensities on magnetic resonance (MR) images and potential risk factors for cerebralExpand
Functional Magnetic Resonance Imaging (fMRI) reproducibility and variance components across visits and scanning sites with a finger tapping task
We present results from the multicentre study 'CaliBrain', examining the reproducibility of fMRI data within and between three sites. Expand
Imaging Approaches for Dementia
  • A. Murray
  • Medicine
  • American Journal of Neuroradiology
  • 1 November 2012
SUMMARY: Brain imaging has progressed from exclusion of rare treatable mass lesions to a specific antemortem diagnosis. MR imaging−derived hippocampal atrophy and WMH are regarded as imagingExpand
What provides cerebral reserve?
The cerebral reserve hypothesis is a heuristic concept used to explain apparent protection from the onset of cerebral disease and/or cognitive decline in old age. A significant obstacle whenExpand
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes
We aggregated coding variant data for 81,412 type 2 diabetes cases and 370,832 controls of diverse ancestry, identifying 40 coding variant association signals (P < 2.2 × 10−7); of these, 16 map outside known risk-associated loci. Expand
Structural white matter deficits in high-functioning individuals with autistic spectrum disorder: a voxel-based investigation
A number of imaging and neuropathological studies have reported structural abnormalities in white matter areas such as the corpus callosum in autism spectrum disorder (ASD). Expand