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Epigenetic Control of rDNA Loci in Response to Intracellular Energy Status
TLDR
eNoSC is described, a protein complex that senses energy status and controls rRNA transcription, and promotes restoration of energy balance by limiting r RNA transcription, thus protecting cells from energy deprivation-dependent apoptosis and providing key insight into the mechanisms of energy homeostasis in cells. Expand
The ubiquitin ligase CHIP acts as an upstream regulator of oncogenic pathways
TLDR
It is demonstrated that CHIP inhibits anchorage-independent cell growth and metastatic potential by degrading oncogenic proteins including SRC-3, which is a direct target for ubiquitylation and degradation by CHIP. Expand
Retracted: Transrepression by a liganded nuclear receptor via a bHLH activator through co‐regulator switching
TLDR
The present study deciphers a novel mechanism of ligand‐induced transrepression by nuclear receptor via co‐regulator switching using a bHLH‐type factor as a direct sequence‐specific activator of 1αnVDRE. Expand
A specific CpG site demethylation in the human interleukin 2 gene promoter is an epigenetic memory
TLDR
The observations indicate that Oct‐1‐binding followed by CpG demethylation are key events in the epigenetic regulation of IL2 expression and may act as a memory of the regulatory event. Expand
Positive and Negative Regulations of the Renal 25-Hydroxyvitamin D3 1α-Hydroxylase Gene by Parathyroid Hormone, Calcitonin, and 1α,25(OH)2D3 in Intact Animals.
TLDR
It is found that the 1α-hydroxylase gene abundantly expresses in kidney, and at low levels in other tissues and in some cell lines, and that vitamin D receptor is essential for the repression by 1α,25(OH)2D3. Expand
Estrogen Inhibits Transforming Growth Factor β Signaling by Promoting Smad2/3 Degradation*
TLDR
The analysis revealed that ERα formed a protein complex with Smad and the ubiquitin ligase Smurf, and enhanced Smad ubiquitination and subsequent degradation in an estrogen-dependent manner, and provided new insight into the molecular mechanisms governing the non-genomic functions of ERα. Expand
Positive and negative regulations of the renal 25-hydroxyvitamin D3 1alpha-hydroxylase gene by parathyroid hormone, calcitonin, and 1alpha,25(OH)2D3 in intact animals.
TLDR
It is demonstrated that PTH and calcitonin positively regulate renal 1alpha-hydroxylase gene expression via PKA-dependent and independent pathway, respectively, and that 1alpha,25(OH)2D3 negatively regulates it mediated by vitamin D receptor. Expand
Ligand‐dependent switching of ubiquitin–proteasome pathways for estrogen receptor
TLDR
The findings suggest that ERα is regulated by two independent ubiquitin–proteasome pathways, which are switched by ligand binding to ERα, and one pathway is necessary for the transactivation of the receptor and the other is involved in the quality control of the receptors. Expand
A nonclassical vitamin D receptor pathway suppresses renal fibrosis.
TLDR
This study found that 1,25-dihydroxyvitamin D3-bound [1,25(OH)2D3- bound] vitamin D receptor (VDR) specifically inhibits TGF-β-SMAD signal transduction through direct interaction with SMAD3. Expand
Estrogen Regulates Tumor Growth Through a Nonclassical Pathway that Includes the Transcription Factors ERβ and KLF5
TLDR
It is demonstrated that the estrogen receptor β (ERβ) mediates inhibition by the antiestrogen ICI 182,780 (ICI) and its enhancement by estrogen, and affects prostate tumor growth through ERβ-mediated regulation of KLF5. Expand
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