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Hormonal contraception and risk of cancer.
BACKGROUND Fear from increased cancer risk is one of the most significant reasons for low acceptance of reliable contraceptive methods and low compliance. METHODS In this review, we included allExpand
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A dose‐ranging study to determine the efficacy and safety of 1, 2, and 4 mg of dienogest daily for endometriosis
To compare the efficacy and safety of dienogest at doses of 1, 2, and 4 mg/day orally in the treatment of endometriosis.
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2-Methoxyestradiol—Biology and mechanism of action
In the last decade the endogenous estradiol metabolite, 2-methoxyestradiol (2ME), has gained more and more interest due to its marked anticancerogenic properties and possible cardiovascular benefits,Expand
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The pharmacology of dienogest.
Dienogest (DNG) is a 19-nortestosterone derivative (a C-19 progestogen) with a cyanomethyl instead of an ethinyl group at the C-17 position, which may make the compound elicit fewer hepatic effectsExpand
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Estradiol metabolism and malignant disease.
Endogenous estradiol metabolism results in metabolic products that are still capable of exerting various biological, partially estrogen-antagonistic actions. This indicates that the effects ofExpand
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The effects of A-ring and D-ring metabolites of estradiol on the proliferation of vascular endothelial cells.
The effects of 14 estradiol metabolites on the proliferation of cultured endothelial cells of human umbilical cord veins were examined and compared with that of their parent substance estradiol. TheExpand
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Medroxyprogesterone acetate versus norethisterone: effect on estradiol-induced changes of markers for endothelial function and atherosclerotic plaque characteristics in human female coronary
ObjectiveProgestin addition to estradiol (E2) replacement therapy may lead to a deterioration of beneficial effects on the vasculature. The effect of the two clinically most common progestins,Expand
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Effect of estradiol metabolites on the susceptibility of low density lipoprotein to oxidation.
The main estradiol metabolites 2-hydroxyestrone, 2-methoxyestrone and 16alpha-hydroxyestrone were investigated in vitro for the susceptibility of low density lipoprotein to oxidation and the effectsExpand
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The pharmacology of nomegestrol acetate.
Nomegestrol acetate (NOMAC) is a 19-norprogesterone derivative with high biological activity at the progesterone receptor, a weak anti-androgenic effect, but with no binding to estrogen,Expand
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Effects of drospirenone on cardiovascular markers in human aortic endothelial cells
Objectives The effect of the new progestogen drospirenone on biochemical markers in terms of cardiovascular effects was investigated in the presence and absence of aldosterone and compared toExpand
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