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1H HR‐MAS and genomic analysis of human tumor biopsies discriminate between high and low grade astrocytomas
TLDR
1H HR‐MAS spectra provide in addition the genetic background for the alterations of choline metabolism observed in high and low grade gliomas, a result that could not be obtained using the tCho/Cr ratio commonly used by in vivo 1H NMR spectroscopy.
Lung surfactant metabolism: early in life, early in disease and target in cell therapy
TLDR
Two recent cell therapies that aim to recover the activity of AE2C or AM are reviewed, therefore targeting the restoring of surfactant metabolism and lung homeostasis.
Ex vivo HR-MAS magnetic resonance spectroscopy of normal and malignant human renal tissues.
TLDR
Ex vivo HR-MAS MRS is demonstrated to be a viable and powerful means of probing for molecular information in human normal and tumoral renal tissues and will constitute the basis for a biochemical classification of renal neoplastic pathologies.
Pulmonary transplantation of macrophage progenitors as effective and long-lasting therapy for hereditary pulmonary alveolar proteinosis
TLDR
The concept of organotopic transplantation of macrophage progenitors as an effective and long-lasting therapy of herPAP is presented and may also serve as a proof of principle for other diseases, expanding current stem cell–based strategies toward potent concepts using the transplantations of differentiated cells.
Gene correction of human induced pluripotent stem cells repairs the cellular phenotype in pulmonary alveolar proteinosis.
TLDR
PAP-iPSC-derived monocytes and macrophages are established as a valid in vitro disease model of CSF2RA-deficient PAP, and gene-corrected iPSC -derived monocyte and macophages are introduced as a potential autologous cell source for innovative therapeutic strategies.
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