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Vitamin D3 promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of β-catenin signaling
1α,25(OH)2D3 induces E-cadherin and modulates β-catenin–TCF-4 target genes in a manner opposite to that of β- catenin, promoting the differentiation of colon carcinoma cells. Expand
Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer
It is shown for the first time that another extracellular Wnt inhibitor, the DICKKOPF-1 (DKK-1) gene, is transcriptionally silenced by CpG island promoter hypermethylation in colon cancer cell lines, whereas treatment with the DNA-demethylating agent 5-aza-2-deoxycytidine restored DKK- 1 expression. Expand
Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway.
Evidence is presented that hormone-activated nuclear receptors prevent c-Jun phosphorylation on Ser-63/73 and, consequently, AP-1 activation, by blocking the induction of the JNK signaling cascade. Expand
Role of HuR in Skeletal Myogenesis through Coordinate Regulation of Muscle Differentiation Genes
It is found that at the onset of myogenesis in differentiating C2C12 myocytes and in vivo in regenerating mouse muscle, HuR cytoplasmic abundance increased dramatically, returning to a predominantly nuclear presence upon completion of my genesis. Expand
The Wnt antagonist DICKKOPF-1 gene is a downstream target of β-catenin/TCF and is downregulated in human colon cancer
The data indicate that the Wnt/β-catenin pathway is downregulated by the induction of DKK-1 expression, a mechanism that is lost in colon cancer. Expand
The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer
It is shown that the SNAIL transcription factor represses VDR gene expression in human colon cancer cells and blocks the antitumor action of EB1089, a 1,25(OH)2D3 analog, in xenografted mice. Expand
DICKKOPF-4 is induced by TCF/β-catenin and upregulated in human colon cancer, promotes tumour cell invasion and angiogenesis and is repressed by 1α,25-dihydroxyvitamin D3
DKK-4 is upregulated in colon cancer and is associated with the acquisition of malignant properties by neoplastic cells and downregulation is a novel effect of 1,25(OH)2D3 that may contribute to its anticancer action. Expand
The c-erb-A protein is a high-affinity receptor for thyroid hormone
Hormone binding and localization of the c-erb-A protein suggest that it is a receptor for thyroid hormone, a nuclear protein that binds to DNA and activates transcription. In contrast, the product ofExpand
β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer
It is shown that it is possible to evaluate the β-catenin status of patients' carcinomas and the response of patient-derived cells to target-directed drugs that accumulate FOXO3a in the nucleus before deciding on a course of treatment, and it is proposed that this evaluation could be essential to the provision of a safer and more effective personalized treatment. Expand
v-erbA oncogene activation entails the loss of hormone-dependent regulator activity of c-erbA
It is shown that the overexpressed thyroid hormone receptor c-erbA effectively modulates erythroid differentiation and erythrocyte-specific gene expression in a T3-dependent fashion, when introduced into erystroid cells via a retrovirus. Expand