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Malaria in Uganda: challenges to control on the long road to elimination: I. Epidemiology and current control efforts.
TLDR
There is no convincing evidence that the burden of malaria has decreased in Uganda in recent years, and major challenges to malaria control include very high malaria transmission intensity, inadequate health care resources, a weak health system, inadequate understanding of malaria epidemiology and the impact of control interventions, and inadequate epidemic preparedness and response. Expand
Comparison of Buccal Midazolam With Rectal Diazepam in the Treatment of Prolonged Seizures in Ugandan Children: A Randomized Clinical Trial
TLDR
B Buccal midazolam was as safe as and more effective than rectal diazepam for the treatment of seizures in Ugandan children, although benefits were limited to children without malaria. Expand
Single dose primaquine for clearance of Plasmodium falciparum gametocytes in children with uncomplicated malaria in Uganda: a randomised, controlled, double-blind, dose-ranging trial.
TLDR
No children showed evidence of treatment-related haemolysis, and the mean maximum decrease in haemoglobin concentration was not associated with the dose of primaquine received-it did not differ significantly compared with placebo, calling for the prioritisation of further trials into the efficacy and safety of doses ofPrimaquine. Expand
Anti-malarial prescription practices among outpatients with laboratory-confirmed malaria in the setting of a health facility-based sentinel site surveillance system in Uganda
TLDR
High rates of compliance with recommended ACT use can be achieved in resource-limited settings, and the unique health facility-based malaria surveillance system operating at these clinical sites may provide a framework for improving appropriate ACT use at other sites in sub-Saharan Africa. Expand
Combination treatments for uncomplicated falciparum malaria in Kampala, Uganda: randomised clinical trial
TLDR
Combinations of amodiaquine and sulfadoxine-pyrimethamine or artesunate were significantly more efficacious, and each regimen could be an appropriate alternative for treatment of uncomplicated malaria in Africa. Expand
Resurgence of Malaria Following Discontinuation of Indoor Residual Spraying of Insecticide in an Area of Uganda With Previously High-Transmission Intensity
TLDR
Discontinuation of IRS in an area of Uganda with historically high transmission intensity was associated with a rapid increase in malaria morbidity to pre-IRS levels. Expand
Metagenomic next-generation sequencing of samples from pediatric febrile illness in Tororo, Uganda
TLDR
The near complete genome of a highly divergent orthobunyavirus, tentatively named Nyangole virus, is identified from the serum of a child diagnosed with malaria and pneumonia, a Bwamba orthob UNavirus in the nasopharynx of a children with rash and sepsis, and the genomes of two novel human rhinovirus C species are reported. Expand
Cytoadherence in paediatric malaria: ABO blood group, CD36, and ICAM1 expression and severe Plasmodium falciparum infection
TLDR
Host genetic adaptations to Plasmodium falciparum suggest new potential malaria treatment strategies and a significant survival advantage attributed to blood group O and increased monocyte expression of CD36 and ICAM1 is reported. Expand
Demographic, Socioeconomic, and Geographic Factors Leading to Severe Malaria and Delayed Care Seeking in Ugandan Children: A Case-Control Study.
TLDR
Delayed care seeking and seeking care at a drug shop were risk factors for severe malaria and the role of drug shops in contributing to delayed care and risk of severe malaria requires further study. Expand
Measures of Malaria Burden after Long-Lasting Insecticidal Net Distribution and Indoor Residual Spraying at Three Sites in Uganda: A Prospective Observational Study
TLDR
High-quality surveillance evaluated malaria metrics and mosquito exposure before and after interventions through enhanced health-facility-based surveillance to estimate malaria test positivity rate (TPR) and entomology surveys to estimate household-level human biting rate (HBR). Expand
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