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High extracellular inorganic phosphate concentration inhibits RANK–RANKL signaling in osteoclast‐like cells
In this work, we investigated the effect of inorganic phosphate (Pi) on the differentiation of monocyte/macrophage precursors into an “osteoclastic” phenotype, and we delineated the molecularExpand
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Indoxyl sulphate inhibits osteoclast differentiation and function.
BACKGROUND Patients with chronic kidney disease (CKD) develop various bone abnormalities characterized by impaired bone remodelling. Recent data suggest that accumulation of the uraemic toxin indoxylExpand
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The pathophysiology of vascular calcification: are osteoclast-like cells the missing link?
There is increasing evidence to suggest that the initiation of vascular calcification is an active process involving vascular smooth muscle cell (VSMC) apoptosis and trans-differentiation intoExpand
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Tumor Necrosis Factor‐Related Apoptosis‐Inducing Ligand and Vascular Calcification
Vascular calcification is frequent in patients with chronic kidney disease. Osteoprotegerin (OPG, a soluble factor which blocks osteoclast differentiation) has recently been implicated in the genesisExpand
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Pathophysiological mechanisms and consequences of cardiovascular calcifications: role of uremic toxicity.
SUMMARY Chronic kidney disease (CKD) represents an accelerated model of the active cardiovascular calcification process. Recent data from our laboratory indicate the presence of a possible vascularExpand
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Uremic Toxin Indoxyl Sulfate Inhibits Human Vascular Smooth Muscle Cell Proliferation
Uremic syndrome is attributed to the progressive retention of a large number of compounds, such as indoxyl sulfate, which under physiological conditions are excreted by the kidneys. Previous in vitroExpand
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Parathyroid Hormone-Related Peptide (1-36) Enhances Beta Cell Regeneration and Increases Beta Cell Mass in a Mouse Model of Partial Pancreatectomy
Aims/Hypothesis Finding ways to stimulate the regeneration of endogenous pancreatic beta cells is an important goal in the treatment of diabetes. Parathyroid hormone-related protein (PTHrP), theExpand
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Lactogens protect rodent and human beta cells against glucolipotoxicity-induced cell death through Janus kinase‐2 (JAK2)/signal transducer and activator of transcription-5 (STAT5) signalling
Aims/hypothesisA leading cause of type 2 diabetes is a reduction in functional beta cell mass partly due to increased beta cell death, triggered by stressors such as glucolipotoxicity (GLT). ThisExpand
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Systemic and acute administration of parathyroid hormone-related peptide(1–36) stimulates endogenous beta cell proliferation while preserving function in adult mice
Aims/hypothesisA major focus in the treatment of diabetes is to identify factors that stimulate endogenous beta cell growth while preserving function. The first 36 amino acids of parathyroidExpand
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Growth Factor Mediated Regulation of Beta Cell Survival
Numerous studies have shown that a reduction in the endogenous functional � -cell mass is a major cause of every form of diabetes. Therefore, the development of therapies to preserve and regenerateExpand
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