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Methionine to isothreonine conversion as a source of false discovery identifications of genetically encoded variants in proteogenomics.
TLDR
An artifact of sample preparation which mimics methionine to threonine nucleic acid-encoded variant is described, which should be taken into consideration for correct interpretation of proteogenomic data. Expand
Targeted Quantitative Screening of Chromosome 18 Encoded Proteome in Plasma Samples of Astronaut Candidates.
TLDR
This work was aimed at estimating the concentrations of proteins encoded by human chromosome 18 (Chr 18) in plasma samples of 54 healthy male volunteers (aged 20-47) and provides a background for studies of a potential biomarker in plasma among proteins encode by Chr 18. Expand
Spaceflight Effects on Cytochrome P450 Content in Mouse Liver
TLDR
The induction of enzyme observed in the mice in the conditions of the spaceflight could lead to an accelerated biotransformation and change in efficiency of pharmacological agents, metabolizing by corresponding CYP isoforms. Expand
Enhanced oligomerization of full-length RAGE by synergy of the interaction of its domains
TLDR
The data provide experimental evidence for the major role of the C2 and TM domains in oligomerization, underscoring synergy among different oligomersization contact regions along the RAGE sequence, and explain the variability of obtained oligomerized modes in RAGE fragments. Expand
Threonine versus isothreonine in synthetic peptides analyzed by high-resolution liquid chromatography/tandem mass spectrometry.
TLDR
Threonine can be distinguished from isothreonine by its retention time and HCD fragmentation pattern, specifically relative intensity of the bn - product ion, which can be further used in proteomic research. Expand
Brochosomins and other novel proteins from brochosomes of leafhoppers (Insecta, Hemiptera, Cicadellidae).
TLDR
It is demonstrated that the major structural component of BS of the leafhopper Graphocephala fennahi Young is a novel family of 21-40-kDa secretory proteins, referred to herein as brochosomins (BSM), apparently cross-linked by disulfide bonds. Expand
Formation of highly stable multinuclear AgnSn clusters in zinc fingers disrupts their structure and function.
TLDR
A compact eight-membered Ag4S4 structure formed by a CCCC ZF is the first cluster example reported for a single biological molecule. Expand
[Way to the peptide vaccine against hepatitis C].
TLDR
Experiments on laboratory animals demonstrated that the developed peptide constructs manifested immunogenicity compared with one of protein molecules and were able to raise antibodies, which specifically bound HCV envelope proteins, which succeeded in obtaining antibodies reactive with HCV from hepatitis C patient plasma upon the immunization with some constructs. Expand
Use of DNA-Aptamers for Enrichment of Low Abundant Proteins in Cellular Extracts for Quantitative Detection by Selected Reaction Monitoring
The relationship between the amount of a target protein in a complex biological sample and its amount measured by selected reaction monitoring (SRM) mass spectrometry upon the affinity enrichment ofExpand
[Use of DNA-aptamers for enrichment of low abundant proteins in cellular extracts for quntitative detection by selected reaction monitoring].
TLDR
It has been demonstrated that the affinity enrichment of thrombin in cellular extracts by means of theThrombin-binding aptamer immobilized on the surface of magnetic microbeads results in an approximately 10-fold increase of the concentration of target protein and a 100-fold decrease of the low limit of a target protein concentration range where its quantitative detection by SRM is possible without an interference from other peptides present in a tryptic digest. Expand
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