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Lipid Accumulation Product (LAP) and Visceral Adiposity Index (VAI) as Markers of Insulin Resistance and Metabolic Associated Disturbances in Young Argentine Women with Polycystic Ovary Syndrome.
TLDR
Both LAP and VAI showed to be more effective markers to assess MD and IR in these young women than TG/HDl-c or TC/HDL-c [cut-off values: LAP: 18.24, VAI: 2.19], and are representative markers to assessment MD associated with IR in young PCOS patients. Expand
The mechanisms involved in the action of metformin in regulating ovarian function in hyperandrogenized mice.
TLDR
Investigation of the mechanisms by which N,N'-dimethylbiguanide metformin prevents the ovarian disorders provoked by the hyperandrogenization with dehydroepiandrosterone (DHEA) in prepuberal BALB/c mice found it to prevent the increase of ovarian iNOS and COX2 expressions and to enhance the activation of phosphorylated AMPK-alpha expression. Expand
Effects of dehydroepiandrosterone on ovarian cystogenesis and immune function.
TLDR
Results show that the development of cysts involves changes in ovarian function and an imbalance in the oxidant-antioxidant equilibrium. Expand
Dual effects of nitric oxide in functional and regressing rat corpus luteum.
TLDR
Results indicate that the NO could act with a dual action (protective or pro-oxidant) in CL development, supported by the fact that in-vivo PGF(2 alpha) treatment enhanced nitric oxide synthase (NOS) activity. Expand
Prenatal Hyperandrogenization Induces Metabolic and Endocrine Alterations Which Depend on the Levels of Testosterone Exposure
TLDR
The data show that the levels of testosterone prenatally injected modulate the uterine environment and that this, in turn, would be responsible for the endocrine and metabolic abnormalities and the phenotype of PCOS during the adult life. Expand
Hyperandrogenism alters intraovarian parameters during early folliculogenesis in mice.
TLDR
It is concluded that the excess of androgens impairs early follicular development by modulating some endocrine and immune parameters that are either directly or indirectly related to follicular atresia. Expand
Systemic inflammation, cellular influx and up-regulation of ovarian VCAM-1 expression in a mouse model of polycystic ovary syndrome (PCOS).
TLDR
Novel evidence is presented that the immune system is activated systemically and locally in a mouse model of PCOS elicited by androgenisation using dehydroepiandrosterone (DHEA), and it is proposed that VCAM-1 is involved in aggravating PCOS symptoms by promoting leukocyte recruitment to the ovaries and perpetuating local inflammation. Expand
Alterations of folliculogenesis in women with polycystic ovary syndrome
TLDR
It is concluded that despite the hyper-luteinized environment of PCOS follicles, these follicles produce lower levels of progesterone and estradiol, and that this is characterized by increased degradation of progestersone and decreased est radiol synthesis. Expand
Impaired immune responses in streptozotocin‐induced type I diabetes in mice. Involvement of high glucose
TLDR
Results indicate that HG concentrations can directly affect lymphoid cell growth and suggest that prolonged exposure to pathologically HG concentrations would result in the immunosuppressive state observed in diabetes. Expand
Role of the N, N'-dimethylbiguanide metformin in the treatment of female prepuberal BALB/c mice hyperandrogenized with dehydroepiandrosterone.
TLDR
Results indicate that metformin is able, directly or indirectly, to avoid the endocrine and immune alterations produced when mice are hyperandrogenized with DHEA. Expand
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